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Study · Randomized controlled trial · 1990

2 results

Comparison of intramuscular glucagon and intravenous dextrose in the treatment of hypoglycaemic coma in an accident and emergency department.

Patrick AW, Collier A, Hepburn DA, Steedman DJ, Clarke BF, Robertson C

Archives of emergency medicine1 Jun 1990Cited by 29 (Europe PMC)

PMID2390157 (opens in a new tab)PMCIDPMC1285671 (opens in a new tab)DOI10.1136/emj.7.2.73 (opens in a new tab)PepBankPUB-02390157
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with hypoglycaemic coma, recovery of consciousness took longer with glucagon than dextrose: 9.0 versus 3.0 min.

    In plain wordsIn patients with hypoglycaemic coma, consciousness returned more slowly with glucagon than intravenous dextrose.

    Peptide
    Glucagon
    Outcome
    IncreaseTime to normal consciousness
    Study

    n: not reported in source

    Comparator
    Intravenous dextrose, 25 g
    Outcome group
    Hypoglycemia Recovery · Nervous system and cognition
    Studied dose
    1 mg · intramuscularAs given in this study (human).

    Measurements

    Recovery time
    9 min
    glucagon
    Recovery time
    3 min
    dextrose

    Source sentences

    Summary
    Restoration of normal conscious level was slower after glucagon than dextrose (9.0 vs 3.0 min, P less than 0.01), although the average duration of hypoglycaemic coma was 120 min.
    1 context sentence
    Summary · context
    In this study, patients attending an accident and emergency department in hypoglycaemic coma were randomized to treatment with either intravenous dextrose (25g) or intramuscular glucagon (1mg), administered into the right thigh.
  2. 02HumanNon-randomized trialEfficacy outcome

    In hypoglycaemic coma, two glucagon-treated patients required intravenous dextrose after inadequate recovery at 15 min.

    In plain wordsTwo patients with hypoglycaemic coma needed intravenous dextrose after glucagon did not provide satisfactory recovery.

    Peptide
    Glucagon
    Outcome
    Direction not reportedAdditional dextrose for inadequate recovery
    Study

    n: not reported in source

    Outcome group
    Hypoglycemia Recovery · Nervous system and cognition
    Studied dose
    1 mg · intramuscularAs given in this study (human).

    Measurements

    Patients requiring additional dextrose
    2 patients
    glucagon group

    Source sentences

    Summary
    Two patients in the glucagon-treated group, who failed to show satisfactory recovery after 15 min, required additional treatment with intravenous dextrose.
    1 context sentence
    Summary · context
    In this study, patients attending an accident and emergency department in hypoglycaemic coma were randomized to treatment with either intravenous dextrose (25g) or intramuscular glucagon (1mg), administered into the right thigh.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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