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Study · Measured the body's own peptide · 1990

4 results

Changes in circulating levels of neuroendocrine and thymic hormones during aging in rats: a correlation study.

Goya RG, Naylor PH, Goldstein AL, Meites J

Experimental gerontology1 Jan 1990Cited by 10 (Europe PMC)

PMID2369930 (opens in a new tab)DOI10.1016/0531-5565(90)90046-5 (opens in a new tab)PepBankPUB-02369930
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In male Sprague-Dawley rats, serum thymosin alpha‑1 was lower in old (26 month) than in young (3 month) rats.

    In plain wordsIn rats, the body's own thymosin alpha‑1 level was lower in old animals than in young animals.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum thymosin alpha 1 with age
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, 3 and 26 months old
    Comparator
    Young (3 month) rats
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    whereas GH, T4, T alpha 1, and thymus weight showed a significant age-related reduction.
    1 context sentence
    Summary · context
    In order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 month) and old (26 month) male Sprague-Dawley rats.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In male Sprague-Dawley rats, anterior pituitary weight showed a highly significant linear correlation with serum thymosin alpha‑1 (p less than 0.01).

    In plain wordsIn rats, the weight of the pituitary gland was linked to the body's own thymosin alpha‑1 level.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedCorrelation of anterior pituitary weight with thymosin alpha 1
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, 3 and 26 months old
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Three pairs of parameters showed highly significant levels of linear correlation: AP weight vs. T alpha 1; thymus weight vs. T4 and T alpha 1 vs. T4 (p less than 0.01, p less than 0.001 and p less than 0.001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
    1 context sentence
    Summary · context
    In order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 month) and old (26 month) male Sprague-Dawley rats.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In male Sprague-Dawley rats, serum thymosin alpha‑1 showed a highly significant linear correlation with thyroxine (p less than 0.001).

    In plain wordsIn rats, the body's own thymosin alpha‑1 level was linked to the thyroxine level.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedCorrelation of thymosin alpha 1 with thyroxine
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, 3 and 26 months old
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Three pairs of parameters showed highly significant levels of linear correlation: AP weight vs. T alpha 1; thymus weight vs. T4 and T alpha 1 vs. T4 (p less than 0.01, p less than 0.001 and p less than 0.001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
    1 context sentence
    Summary · context
    In order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 month) and old (26 month) male Sprague-Dawley rats.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, the body's own serum thymosin beta‑4 level did not differ significantly between young and old rats.

    In plain wordsIn rats, natural thymosin beta‑4 levels did not differ between young and old animals.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeSerum thymosin beta 4 with age
    Study

    ratn: not reported in source

    Comparator
    Young (3 month) rats
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    The circulating levels of T3, PRL, corticosterone and T beta 4 did not show significant differences between young and old rats
    1 context sentence
    Summary · context
    In order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 month) and old (26 month) male Sprague-Dawley rats.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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