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Study · Measured the body's own peptide · 1990

4 results

Differential splicing of thymosin beta 4 mRNA.

Rudin CM, Engler P, Storb U

Journal of immunology (Baltimore, Md. : 1950)1 Jun 1990Cited by 19 (Europe PMC)

PMID2351831 (opens in a new tab)DOI10.4049/jimmunol.144.12.4857 (opens in a new tab)PepBankPUB-02351831
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    The long thymosin beta‑4 mRNA was present in two pre-B cell lines, spleen and thymus, but was not detected in brain, liver and kidney.

    In plain wordsThe long form of the body's own thymosin beta‑4 mRNA was found in mouse immune cells and tissues, not in brain, liver or kidney.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTissue distribution of long Tβ4 mRNA
    Study

    mousen: not reported in source

    two pre-B cell lines and mouse tissues
    Outcome group
    Gene expression · Immune and inflammation

    Source sentences

    Summary
    The long mRNA is present in two different pre-B cell lines, spleen and thymus, but could not be detected in brain, liver, and kidney.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In a mouse pre-B cell line, two sizes of thymosin beta‑4 mRNA exist: a long form with a 98 nucleotide insertion and a short form like the known rat and human mRNA.

    In plain wordsIn mouse immune cells, two forms of the body's own thymosin beta‑4 mRNA were found, a long and a short form.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTwo sizes of Tβ4 mRNA
    Study

    mousen: not reported in source

    mouse pre-B cell line
    Outcome group
    Gene expression · Immune and inflammation

    Measurements

    insertion length
    98 nucleotides
    long mRNA form

    Source sentences

    Summary
    Furthermore, it was shown by RNase protection assays with RNA from the pre-B cell line that two sizes of thymosin beta 4 mRNA exist, a long form containing the 98 nucleotide insertion, and a short form that corresponds to the known rat and human mRNA.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    The short form of thymosin beta‑4 mRNA was about 50 times more abundant than the long form.

    In plain wordsIn mouse immune cells, the short form of the body's own thymosin beta‑4 mRNA was far more common than the long form.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAbundance of short versus long Tβ4 mRNA
    Study

    mousen: not reported in source

    mouse pre-B cell line
    Outcome group
    Gene expression · Immune and inflammation

    Measurements

    abundance ratio short to long form
    ≈ 50-fold
    mouse pre-B cell line

    Source sentences

    Summary
    The short form is about 50 times more abundant than the long form.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    The two thymosin beta‑4 mRNA forms arise by differential splicing of a single mouse gene: the long mRNA has three exons and the short mRNA lacks exon 2.

    In plain wordsIn mouse cells, one gene for the body's own thymosin beta‑4 makes two mRNA forms. The short form lacks exon 2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableDifferential splicing of Tβ4 mRNA
    Study

    mousen: not reported in source

    mouse pre-B cell line and genomic DNA
    Outcome group
    Gene expression · Immune and inflammation

    Source sentences

    Summary
    The two forms of mRNA arise by differential RNA splicing; the long mRNA contains three separate exons, whereas the short mRNA is missing exon 2.
    1 context sentence
    Summary · context
    Analysis of genomic DNA by sequencing and Southern blotting revealed that both forms are encoded by a single gene in the mouse.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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