In insulin-dependent diabetic subjects, pulsatile glucagon produced higher glucose than continuous delivery: 12.9 +/- 0.4 versus 10.8 +/- 0.3 mmol/l.
In plain wordsIn insulin-dependent diabetic subjects, pulsatile glucagon raised blood glucose more than continuous glucagon.
- Peptide
- Glucagon
- Outcome
- IncreasePlasma glucose during final 65 min
- Study
n = 7
- Comparator
- Continuous glucagon, 58 ng/min
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- 377 ng/min during 2 min followed by 11 min without infusion · intravenousAs given in this study (human).
Measurements
- Plasma glucose
- 12.9 mmol/l
- pulsatile
- Plasma glucose
- 10.8 mmol/l
- continuous
Source sentences
In particular in the last 65 min plasma glucose levels reached 10.8 +/- 0.3 vs 12.9 +/- 0.4 mmol/l (p less than 0.05) during continuous and pulsatile glucagon delivery respectively.
2 context sentences(design, population, supporting numbers)
The study was performed in seven insulin-dependent diabetic subjects proven to have no residual insulin secretion.
In random order and in different days each subject was submitted to glucagon delivery given continuously (58 ng/min) and in a pulsatile (377 ng/min during 2 min followed by 11 min during which no glucagon was infused) manner.