In T-lymphocytes from uremic patients incubated in human serum, the thymosin beta‑4 analog with D-Ala in place of the acetyl group restored the impaired blastogenic response.
In plain wordsIn lab tests on uremic blood cells, an altered thymosin beta‑4 analog (D-Ala) restored a weakened immune cell response.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseBlastogenic response of T-lymphocytes (D-Ala analog)
- Study
humann: not reported in source
T-lymphocytes from uremic patients incubated in human serum- Outcome group
- Immune response · Immune and inflammation
Source sentences
One of the synthetic analogs, D-Ala-thymosin beta 4 demonstrated a restorative effect on these patients when incubated in human serum
1 context sentence(design, population, supporting numbers)
Two analogs of thymosin beta 4 the N-terminal acetyl groups of which were substituted by Ala or D-Ala, were synthesized by the solution method and studied for their immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).