Glucose turnover and recycling in diabetes secondary to total pancreatectomy: effect of glucagon infusion.

Vigili de Kreutzenberg S, Maifreni L, Lisato G, Riccio A, Trevisan R, Tiengo A, Del Prato S

The Journal of clinical endocrinology and metabolism1 Apr 1990Cited by 12 (Europe PMC)

PMID2180971DOI10.1210/jcem-70-4-1023PepBankPUB-02180971

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, adding glucagon to insulin increased plasma glucose to 8.7 +/- 1.5 mmol/L.
In plain wordsIn pancreatectomized patients, adding glucagon to insulin increased blood glucose.
Peptide
Glucagon
Outcome
IncreasePlasma glucose
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Plasma glucose
8.7 mmol/L
glucagon with insulin
Source sentences
Summary
Insulin/glucagon infusion increased plasma glucose concentration (8.7 +/- 1.5 mmol/L), total turnover (18.1 +/- 1.7 mumol/kg.min), and percent recycling (20.4 +/- 6.6%) to values similar to those in type 1 diabetic subjects.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097101
02HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, adding glucagon to insulin increased total glucose turnover to 18.1 +/- 1.7 mumol/kg.min.
In plain wordsIn pancreatectomized patients, adding glucagon to insulin increased glucose turnover.
Peptide
Glucagon
Outcome
IncreaseTotal glucose turnover
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Total turnover
18.1 mumol/kg.min
glucagon with insulin
Source sentences
Summary
Insulin/glucagon infusion increased plasma glucose concentration (8.7 +/- 1.5 mmol/L), total turnover (18.1 +/- 1.7 mumol/kg.min), and percent recycling (20.4 +/- 6.6%) to values similar to those in type 1 diabetic subjects.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097102
03HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, adding glucagon to insulin increased glucose recycling to 20.4 +/- 6.6%.
In plain wordsIn pancreatectomized patients, adding glucagon to insulin increased glucose recycling.
Peptide
Glucagon
Outcome
IncreaseGlucose recycling
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Glucose recycling
20.4%
glucagon with insulin
Source sentences
Summary
Insulin/glucagon infusion increased plasma glucose concentration (8.7 +/- 1.5 mmol/L), total turnover (18.1 +/- 1.7 mumol/kg.min), and percent recycling (20.4 +/- 6.6%) to values similar to those in type 1 diabetic subjects.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097103
04HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, glucagon with insulin significantly lowered alanine versus insulin alone, to 179 +/- 24 mumol/L.
In plain wordsIn pancreatectomized patients, glucagon with insulin lowered blood alanine compared with insulin alone.
Peptide
Glucagon
Outcome
DecreaseBlood alanine
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Amino Acid Metabolism · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Alanine
179 mumol/L
glucagon with insulin
Source sentences
Summary
The change in glucose metabolism was associated with a significant drop in blood concentrations of alanine (179 +/- 24 mumol/L), lactate (611 +/- 25 mumol/L), and pyruvate (30 +/- 3 mumol/L; all P less than 0.05-0.01 vs. insulin infusion alone).
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097104
05HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, glucagon with insulin significantly lowered lactate versus insulin alone, to 611 +/- 25 mumol/L.
In plain wordsIn pancreatectomized patients, glucagon with insulin lowered blood lactate compared with insulin alone.
Peptide
Glucagon
Outcome
DecreaseBlood lactate
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Glucose Metabolism · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Lactate
611 mumol/L
glucagon with insulin
Source sentences
Summary
The change in glucose metabolism was associated with a significant drop in blood concentrations of alanine (179 +/- 24 mumol/L), lactate (611 +/- 25 mumol/L), and pyruvate (30 +/- 3 mumol/L; all P less than 0.05-0.01 vs. insulin infusion alone).
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097105
06HumanNon-randomized trialEfficacy outcome
In pancreatectomized patients, glucagon with insulin significantly lowered pyruvate versus insulin alone, to 30 +/- 3 mumol/L.
In plain wordsIn pancreatectomized patients, glucagon with insulin lowered blood pyruvate compared with insulin alone.
Peptide
Glucagon
Outcome
DecreaseBlood pyruvate
Study
n = 7
Comparator
Insulin infusion alone
Outcome group
Glucose Metabolism · Metabolic and weight
Studied dose
2 ng/kg.min · infusion · overnightAs given in this study (human).
Measurements
Pyruvate
30 mumol/L
glucagon with insulin
Source sentences
Summary
The change in glucose metabolism was associated with a significant drop in blood concentrations of alanine (179 +/- 24 mumol/L), lactate (611 +/- 25 mumol/L), and pyruvate (30 +/- 3 mumol/L; all P less than 0.05-0.01 vs. insulin infusion alone).
1 context sentence(design, population, supporting numbers)
Summary · context
Seven PX patients were studied on two different occasions: 1) after an overnight insulin infusion (0.15 mU/kg.min) and 2) after an overnight insulin/glucagon infusion (2 ng/kg.min).
Report a problemFND-0218097106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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