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Study · Animal study (in vivo) · rat · 1990

3 results

GnRH receptors in rat brain, pituitary and testis; modulation following surgical and gonadotropin-releasing hormone agonist-induced castration.

Ban E, Crumeyrolle-Arias M, Latouche J, Leblanc P, Heurtier JF, Drieu K, Fillion G, Haour F

Molecular and cellular endocrinology1 Mar 1990Cited by 19 (Europe PMC)

PMID2160386 (opens in a new tab)DOI10.1016/0303-7207(90)90063-e (opens in a new tab)PepBankPUB-02160386
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, triptorelin reduced pituitary GnRH receptors by 50% after 8 hours and 80% on days 1-30.

    In plain wordsIn rats, triptorelin reduced pituitary GnRH receptors compared with control levels.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePituitary GnRH receptors
    Study

    ratn: not reported in source

    Male rat brain, pituitary and testis
    Comparator
    Control levels
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg/monthAs given in this study (rat).

    Measurements

    Receptor reduction
    50%
    8 h
    Receptor reduction
    80%
    days 1-30

    Source sentences

    Summary
    Castrating doses of triptorelin strongly down-regulated pituitary GnRH receptors (50% of reduction after 8 h, 80% on days 1-30)
    1 context sentence
    Summary · context
    The regulation of rat gonadotropin-releasing hormone (GnRH) receptors in male rat pituitary, hippocampus and testis was studied, in vivo, under steady-state conditions during treatment with D-Trp6 GnRH (triptorelin, slow-release form, at 300 micrograms/kg/month).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, triptorelin transiently reduced hippocampal GnRH receptors by 20% at 8 hours before a rapid return to control levels.

    In plain wordsIn rats, triptorelin briefly reduced hippocampal GnRH receptors compared with controls before levels returned to normal.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedHippocampal GnRH receptors
    Study

    ratn: not reported in source

    Male rat brain, pituitary and testis
    Comparator
    Control levels
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg/monthAs given in this study (rat).

    Measurements

    Receptor reduction
    20%
    8 h

    Source sentences

    Summary
    in contrast, only a transient decrease (20% at 8 h) was observed in the hippocampus with a rapid return to control levels.
    1 context sentence
    Summary · context
    The regulation of rat gonadotropin-releasing hormone (GnRH) receptors in male rat pituitary, hippocampus and testis was studied, in vivo, under steady-state conditions during treatment with D-Trp6 GnRH (triptorelin, slow-release form, at 300 micrograms/kg/month).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rats, triptorelin doubled testicular interstitial GnRH receptors during 5 days, with return to control levels by day 20.

    In plain wordsIn rats, triptorelin doubled testicular GnRH receptors before they returned to control levels.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedTesticular interstitial GnRH receptors
    Study

    ratn: not reported in source

    Male rat brain, pituitary and testis
    Comparator
    Control levels
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg/monthAs given in this study (rat).

    Measurements

    Receptor increase
    2 fold
    during 5 days

    Source sentences

    Summary
    Triptorelin induced a marked (2-fold) increase in GnRH receptors in testicular interstitial tissue during 5 days with a return to control value by day 20.
    1 context sentence
    Summary · context
    The regulation of rat gonadotropin-releasing hormone (GnRH) receptors in male rat pituitary, hippocampus and testis was studied, in vivo, under steady-state conditions during treatment with D-Trp6 GnRH (triptorelin, slow-release form, at 300 micrograms/kg/month).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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