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Study · Not a test of the peptide alone · 1990

6 results

Stability of gonadorelin and triptorelin in aqueous solution.

Helm VJ, Müller BW

Pharmaceutical research1 Dec 1990Cited by 17 (Europe PMC)

PMID2151342 (opens in a new tab)DOI10.1023/a:1015981704133 (opens in a new tab)PepBankPUB-02151342
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

  1. 01LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In aqueous solution, gonadorelin and triptorelin were most stable at an approximate pH of 5.0.

    In plain wordsIn lab tests, gonadorelin and triptorelin were most stable at about pH 5.0.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicablepH of maximum stability
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    pH of maximum stability
    ≈ 5 pH
    gonadorelin and triptorelin in aqueous solution

    Source sentences

    Summary
    The maximum stability of both peptides was shown to be at an approximate pH of 5.0.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  2. 02LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In aqueous solution, acetate buffer had the most favorable effect on stability of gonadorelin and triptorelin, while phosphate buffer caused higher degradation.

    In plain wordsIn lab tests, acetate buffer kept gonadorelin and triptorelin more stable than phosphate buffer.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableEffect of buffer species on degradation
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Acetate has the most favorable effect on stability, while phosphate causes higher degradation.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  3. 03LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In aqueous solution, changing the acetate buffer concentration did not change the degradation behavior of gonadorelin and triptorelin.

    In plain wordsIn lab tests, the amount of acetate buffer did not change how fast gonadorelin and triptorelin broke down.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeEffect of acetate buffer concentration on degradation
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Varying the concentration of acetate buffer does not affect the degradation behavior of the peptides.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  4. 04LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In aqueous solution, a higher phosphate buffer concentration caused higher degradation of gonadorelin and triptorelin.

    In plain wordsIn lab tests, more phosphate buffer made gonadorelin and triptorelin break down faster.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseEffect of phosphate buffer concentration on degradation
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    A higher phosphate concentration in buffer solutions causes higher degradation, however.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  5. 05LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In aqueous solution, the ionic strength of the buffer had no significant influence on the stability of gonadorelin and triptorelin.

    In plain wordsIn lab tests, ionic strength of the buffer did not significantly change the stability of gonadorelin and triptorelin.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeEffect of ionic strength on stability
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The ionic strength of buffer solutions has no significant influence on stability.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  6. 06LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In acetate buffer (0.1 M, pH 5.0) with 3% (w/v) mannitol at 20 degrees C, the predicted t90% was 9.0 years for gonadorelin and 7.7 years for triptorelin.

    In plain wordsIn lab tests, buffered gonadorelin was predicted to keep its strength for 9.0 years at 20 degrees C.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicablePredicted t90% in acetate buffer with mannitol
    Study

    n: not reported in source

    Aqueous solution
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    t90%
    9 years
    gonadorelin, acetate 0.1 M pH 5.0, 3% mannitol, 20 degrees C
    t90%
    7.7 years
    triptorelin, acetate 0.1 M pH 5.0, 3% mannitol, 20 degrees C

    Source sentences

    Summary
    Solutions of gonadorelin and triptorelin, respectively, buffered with acetate (0.1 M, pH 5.0) with 3% (w/v) mannitol as an additive show a predicted t90% of 9.0 years and 7.7 years at 20 degrees C, respectively.
    1 context sentence
    Summary · context
    The influence of pH, temperature, various buffer species at different concentrations, and ionic strength on the stability of gonadorelin and triptorelin in aqueous solution has been studied using stability-indicating high-performance liquid chromatographic methods.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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