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Study · Animal study (in vivo) · mouse · 1990

6 results

Inhibition of the pituitary-gonadal axis in nude male mice by continuous administration of LHRH agonists and antagonists.

Redding TW, Schally AV

The Journal of endocrinology1 Aug 1990Cited by 17 (Europe PMC)

PMID2144873 (opens in a new tab)DOI10.1677/joe.0.1260309 (opens in a new tab)PepBankPUB-02144873
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In nude male mice, triptorelin microcapsules reduced testicular weight compared with controls.

    In plain wordsIn mice, triptorelin microcapsules reduced testicular weight compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTesticular weight
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    25 micrograms/day · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    [D-Trp6]-LHRH microcapsules at either dose also reduced weights of testes and accessory sex organs.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In nude male mice, triptorelin microcapsules reduced testicular weight compared with controls.

    In plain wordsIn mice, triptorelin microcapsules reduced testicular weight compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTesticular weight
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12.5 micrograms/day · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    [D-Trp6]-LHRH microcapsules at either dose also reduced weights of testes and accessory sex organs.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In nude male mice, triptorelin microcapsules reduced accessory sex organ weights compared with controls.

    In plain wordsIn mice, triptorelin microcapsules reduced accessory sex organ weights compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAccessory sex organ weights
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    25 micrograms/day · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    [D-Trp6]-LHRH microcapsules at either dose also reduced weights of testes and accessory sex organs.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In nude male mice, triptorelin microcapsules reduced accessory sex organ weights compared with controls.

    In plain wordsIn mice, triptorelin microcapsules reduced accessory sex organ weights compared with controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAccessory sex organ weights
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12.5 micrograms/day · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    [D-Trp6]-LHRH microcapsules at either dose also reduced weights of testes and accessory sex organs.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In nude male mice, both triptorelin dose groups showed significantly reduced serum LH.

    In plain wordsIn mice, both triptorelin dose groups showed lower serum LH.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSerum LH
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    Serum LH and testosterone were significantly reduced in all groups treated with analogues.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In nude male mice, both triptorelin dose groups showed significantly reduced serum testosterone.

    In plain wordsIn mice, both triptorelin dose groups showed lower serum testosterone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSerum testosterone
    Study

    mousen: not reported in source

    Nude male mice
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    Serum LH and testosterone were significantly reduced in all groups treated with analogues.
    1 context sentence
    Summary · context
    Other groups received microcapsule preparations of the agonist [D-Trp6]-LHRH, releasing 25 or 12.5 micrograms/day for 30 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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