Effect of Decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium.

Pasqualini JR, Cornier E, Grenier J, Vella C, Schatz B, Netter A

Fertility and sterility1 Jun 1990Cited by 24 (Europe PMC)

PMID2140991DOI10.1016/s0015-0282(16)53577-8PepBankPUB-02140991

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanNon-randomized trialMechanism
In patients with uterine leiomyomata, Decapeptyl significantly decreased estradiol concentrations compared with untreated patients.
In plain wordsIn patients with uterine fibroids, Decapeptyl lowered estradiol concentrations compared with untreated patients.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLeiomyoma estradiol
Study
n: not reported in source
Comparator
Untreated patients
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates.
1 context sentence(design, population, supporting numbers)
Summary · context
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France).
Report a problemFND-0214099101
02HumanNon-randomized trialMechanism
In patients with uterine leiomyomata, Decapeptyl significantly decreased estrone sulfate concentrations compared with untreated patients.
In plain wordsIn patients with uterine fibroids, Decapeptyl lowered estrone sulfate concentrations compared with untreated patients.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLeiomyoma estrone sulfate
Study
n: not reported in source
Comparator
Untreated patients
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates.
2 context sentences(design, population, supporting numbers)
Summary · context
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France).
Summary · context
The decrease provoked by D-Trp6-GnRH on estrogens (unconjugated and sulfates) and in PR in the leiomyoma after long treatment, supports the hypothesis that estrogens are implicated in the cause of these tumors.
Report a problemFND-0214099102
03HumanNon-randomized trialMechanism
In patients with uterine leiomyomata, Decapeptyl significantly decreased estradiol sulfate concentrations compared with untreated patients.
In plain wordsIn patients with uterine fibroids, Decapeptyl lowered estradiol sulfate concentrations compared with untreated patients.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLeiomyoma estradiol sulfate
Study
n: not reported in source
Comparator
Untreated patients
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates.
2 context sentences(design, population, supporting numbers)
Summary · context
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France).
Summary · context
The decrease provoked by D-Trp6-GnRH on estrogens (unconjugated and sulfates) and in PR in the leiomyoma after long treatment, supports the hypothesis that estrogens are implicated in the cause of these tumors.
Report a problemFND-0214099103
04HumanNon-randomized trialMechanism
In patients with uterine leiomyomata, prolonged Decapeptyl treatment significantly decreased progesterone receptors in leiomyoma compared with untreated tissue.
In plain wordsIn patients with uterine fibroids, prolonged Decapeptyl treatment lowered progesterone receptors in fibroids compared with untreated tissue.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLeiomyoma progesterone receptors
Study
n: not reported in source
Comparator
Untreated patients
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 3 to 4 monthsAs given in this study (human).
Source sentences
Summary
Progesterone receptors were higher in the leiomyoma than in the myometrium; after a long treatment (3 to 4 months) a significant decrease in both tissues is observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France).
Report a problemFND-0214099104
05HumanNon-randomized trialMechanism
In patients with uterine leiomyomata, prolonged Decapeptyl treatment significantly decreased progesterone receptors in myometrium compared with untreated tissue.
In plain wordsIn patients with uterine fibroids, prolonged Decapeptyl treatment lowered progesterone receptors in uterine muscle compared with untreated tissue.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMyometrium progesterone receptors
Study
n: not reported in source
Comparator
Untreated patients
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 3 to 4 monthsAs given in this study (human).
Source sentences
Summary
Progesterone receptors were higher in the leiomyoma than in the myometrium; after a long treatment (3 to 4 months) a significant decrease in both tissues is observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France).
Report a problemFND-0214099105

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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