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Study · Non-randomized trial · 1990

5 results

Efficacy and safety of intravenous pulsatile gonadotropin-releasing hormone: Lutrepulse for injection.

Santoro N

American journal of obstetrics and gynecology1 Nov 1990Cited by 4 (Europe PMC)

PMID2122733 (opens in a new tab)DOI10.1016/0002-9378(90)91441-e (opens in a new tab)PepBankPUB-02122733
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In women with primary hypothalamic amenorrhea, pulsatile intravenous GnRH resulted in ovulation in 91% of patients.

    In plain wordsIn women with primary hypothalamic amenorrhea, pulsed GnRH treatment led to ovulation in 91% of patients.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseOvulation rate in primary hypothalamic amenorrhea
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    ovulation rate
    91%
    primary hypothalamic amenorrhea

    Source sentences

    Summary
    In 109 women with primary and secondary hypothalamic amenorrhea, pulsatile gonadotropin-releasing hormone (Lutrepulse [gonadorelin acetate] for Injection) was extremely effective, resulting in ovulation in 91% and 96% of patients, respectively.
    1 context sentence
    Summary · context
    A multicenter trial was undertaken to assess the ability of pulsatile gonadotropin-releasing hormone to restore physiologic ovulatory function in women with diminished or absent pulsatile gonadotropin-releasing hormone secretion.
  2. 02HumanNon-randomized trialEfficacy outcome

    In women with secondary hypothalamic amenorrhea, pulsatile intravenous GnRH resulted in ovulation in 96% of patients.

    In plain wordsIn women with secondary hypothalamic amenorrhea, pulsed GnRH treatment led to ovulation in 96% of patients.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseOvulation rate in secondary hypothalamic amenorrhea
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    ovulation rate
    96%
    secondary hypothalamic amenorrhea

    Source sentences

    Summary
    In 109 women with primary and secondary hypothalamic amenorrhea, pulsatile gonadotropin-releasing hormone (Lutrepulse [gonadorelin acetate] for Injection) was extremely effective, resulting in ovulation in 91% and 96% of patients, respectively.
    1 context sentence
    Summary · context
    A multicenter trial was undertaken to assess the ability of pulsatile gonadotropin-releasing hormone to restore physiologic ovulatory function in women with diminished or absent pulsatile gonadotropin-releasing hormone secretion.
  3. 03HumanNon-randomized trialSafety outcome

    In women treated with pulsatile intravenous GnRH, complications of intravenous line placement ranged from 0% to 11%, with a mean of 7%.

    In plain wordsIn women treated with pulsed GnRH, problems with placing the intravenous line occurred in 0% to 11% of cases, 7% on average.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableComplications of intravenous line placement
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    IV line complications (minimum)
    0%
    reported range
    IV line complications (maximum)
    11%
    reported range
    IV line complications (mean)
    7%
    mean

    Source sentences

    Summary
    Overall complications of intravenous line placement ranged from 0% to 11% (mean = 7%).
    1 context sentence
    Summary · context
    A multicenter trial was undertaken to assess the ability of pulsatile gonadotropin-releasing hormone to restore physiologic ovulatory function in women with diminished or absent pulsatile gonadotropin-releasing hormone secretion.
  4. 04HumanNon-randomized trialSafety outcome

    In women treated with pulsatile intravenous GnRH, the incidence of multiple pregnancy was 12%.

    In plain wordsIn women treated with pulsed GnRH, the reported incidence of multiple pregnancy was 12%.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableMultiple pregnancy incidence
    Study

    n: not reported in source

    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Measurements

    multiple pregnancy incidence
    12%
    reported incidence

    Source sentences

    Summary
    A 12% incidence of multiple pregnancy was noted
    1 context sentence
    Summary · context
    A multicenter trial was undertaken to assess the ability of pulsatile gonadotropin-releasing hormone to restore physiologic ovulatory function in women with diminished or absent pulsatile gonadotropin-releasing hormone secretion.

Studies that did not test the peptide alone1

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

  1. 05HumanNot a test of Gonadorelin (GnRH, LHRH) aloneNon-randomized trialSafety outcome

    A single case of ovarian hyperstimulation occurred in a woman who received pulsatile GnRH together with clomiphene citrate.

    In plain wordsOne woman had ovarian hyperstimulation. She also received clomiphene citrate, so the cause cannot be assigned to GnRH alone.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableOvarian hyperstimulation, single case with clomiphene
    Study

    n: not reported in source

    Outcome group
    Adverse events · Reproductive and sexual health

    Source sentences

    Summary
    a single case of ovarian hyperstimulation was reported in a woman who also received clomiphene citrate.
    1 context sentence
    Summary · context
    A multicenter trial was undertaken to assess the ability of pulsatile gonadotropin-releasing hormone to restore physiologic ovulatory function in women with diminished or absent pulsatile gonadotropin-releasing hormone secretion.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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