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Study · Measured the body's own peptide · 1991

3 results

Effects of neonatal sexual differentiation, growth hormone and testosterone on thymic weights and thymosin-beta 4 in hypophysectomized rats.

Wise T, Klindt J, Macdonald GJ, Ford JJ

Journal of reproductive immunology1 Jan 1991Cited by 7 (Europe PMC)

PMID2007995 (opens in a new tab)DOI10.1016/0165-0378(91)90005-b (opens in a new tab)PepBankPUB-02007995
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In hypophysectomized rats, growth hormone increased the concentration of the body's own thymosin beta‑4 in a dose-dependent manner.

    In plain wordsIn rats without a pituitary gland, growth hormone raised the body's own thymosin beta‑4 levels, more so at higher doses.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin-beta 4 concentration after growth hormone
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Administration of growth hormone to hypophysectomized rats increased thymosin-beta 4 concentration in a dose-dependent manner
    1 context sentence
    Summary · context
    Growth hormone (25 micrograms daily), testosterone propionate (100 micrograms/day), and the combination of the two hormonal treatments were administered for seven days, then thymic weights and blood samples were collected.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In hypophysectomized rats, testosterone injection did not change the concentration of the body's own thymosin beta‑4.

    In plain wordsIn rats without a pituitary gland, testosterone did not change the body's own thymosin beta‑4 levels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin-beta 4 concentration after testosterone
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    but injection of testosterone had no effect on thymosin-beta 4 concentrations.
    1 context sentence
    Summary · context
    Growth hormone (25 micrograms daily), testosterone propionate (100 micrograms/day), and the combination of the two hormonal treatments were administered for seven days, then thymic weights and blood samples were collected.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    Hypophysectomized male rats had higher concentrations of the body's own thymosin beta‑4 than female and neonatally androgenized female rats.

    In plain wordsIn rats without a pituitary gland, males had higher natural thymosin beta‑4 levels than females and androgenized females.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin-beta 4 concentration by sex
    Study

    ratn: not reported in source

    Comparator
    Female and neonatally androgenized female rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Hypophysectomized males had increased thymosin-beta 4 concentrations compared with female and neonatally-androgenized female rats.
    1 context sentence
    Summary · context
    Growth hormone (25 micrograms daily), testosterone propionate (100 micrograms/day), and the combination of the two hormonal treatments were administered for seven days, then thymic weights and blood samples were collected.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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