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Study · Measured the body's own peptide · 1991

2 results

Developmental regulation of beta-thymosins in the rat central nervous system.

Lugo DI, Chen SC, Hall AK, Ziai R, Hempstead JL, Morgan JI

Journal of neurochemistry1 Feb 1991Cited by 43 (Europe PMC)

PMID1988550 (opens in a new tab)DOI10.1111/j.1471-4159.1991.tb08172.x (opens in a new tab)PepBankPUB-01988550
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the developing rat nervous system, thymosin beta‑4 polypeptide levels declined by about 20% over the period when thymosin beta 10 fell about 20-fold.

    In plain wordsIn rats, the brain's own thymosin beta‑4 fell by about 20% as the animals matured.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 polypeptide level during brain development
    Study

    ratn: not reported in source

    Developing rat central nervous system
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Measurements

    decline
    ≈ 20%
    thymosin beta 4 polypeptide

    Source sentences

    Summary
    In comparison, the levels of thymosin beta 4 polypeptide, a homologue of thymosin beta 10, only decline by about 20% during the same developmental period.
    1 context sentence
    Summary · context
    HPLC analysis of guanidinium hydrochloride extracts of neonatal and adult rat brain revealed a polypeptide that is present in high concentration in the immature nervous system, but whose levels decline dramatically in the adult.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat brain, thymosin beta‑4 mRNA was elevated in fetal brain and decreased approximately four-fold to a stable value around birth.

    In plain wordsIn rats, mRNA for the body's own thymosin beta‑4 in the brain was high before birth and fell about four-fold around birth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 mRNA during brain development
    Study

    ratn: not reported in source

    Developing rat central nervous system
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Measurements

    decrease
    ≈ 4 fold
    thymosin beta 4 mRNA

    Source sentences

    Summary
    However, the mRNA encoding thymosin beta 4 is elevated in fetal brain, and its levels decrease approximately four-fold to a stable value around the time of birth.
    2 context sentences
    Summary · context
    HPLC analysis of guanidinium hydrochloride extracts of neonatal and adult rat brain revealed a polypeptide that is present in high concentration in the immature nervous system, but whose levels decline dramatically in the adult.
    Summary · context
    In comparison, the levels of thymosin beta 4 polypeptide, a homologue of thymosin beta 10, only decline by about 20% during the same developmental period.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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