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Study · Animal study (in vivo) · guinea pig · 1990

4 results

[Effect of thymic immunomodulators on the system of cyclic nucleotides of splenic T-lymphocytes after BCG vaccination].

Demidov SV, Kostromin AP, Chernyshenko EF, Kuĭbeda VV, Borovok MI

Problemy tuberkuleza1 Jan 1990

PMID1981933 (opens in a new tab)PepBankPUB-01981933
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In guinea pigs during BCG vaccination, thymalin mainly activated cGMP synthesis.

    In plain wordsIn guinea pigs during BCG vaccination, thymalin increased cGMP production.

    Peptide
    Thymalin
    Outcome
    IncreasecGMP synthesis
    Study

    guinea pign: not reported in source

    BCG vaccination
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level.
    1 context sentence
    Summary · context
    The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In guinea pigs during BCG vaccination, thymalin shifted the cAMP/cGMP ratio below the reference level.

    In plain wordsIn guinea pigs during BCG vaccination, thymalin lowered the cAMP/cGMP ratio below the reference level.

    Peptide
    Thymalin
    Outcome
    DecreasecAMP/cGMP ratio
    Study

    guinea pign: not reported in source

    BCG vaccination
    Comparator
    Reference level
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level.
    1 context sentence
    Summary · context
    The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In BCG-vaccinated guinea pigs, thymogen activated cGMP synthesis in splenic T lymphocytes.

    In plain wordsIn guinea pigs given BCG, thymogen increased cGMP synthesis in splenic T lymphocytes.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreasecGMP synthesis
    Study

    guinea pign: not reported in source

    BCG-vaccinated guinea pigs
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level.
    1 context sentence
    Summary · context
    The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In BCG-vaccinated guinea pigs, thymogen shifted the splenic T lymphocyte cAMP/cGMP ratio below the reference level.

    In plain wordsIn guinea pigs given BCG, thymogen lowered the splenic T lymphocyte cAMP/cGMP ratio below the reference level.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreasecAMP/cGMP ratio
    Study

    guinea pign: not reported in source

    BCG-vaccinated guinea pigs
    Comparator
    Reference level
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level.
    1 context sentence
    Summary · context
    The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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