The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.

Schöbitz B, Hannappel E, Brand K

Biochimica et biophysica acta1 Nov 1991Cited by 7 (Europe PMC)

PMID1958698DOI10.1016/0167-4889(91)90104-6PepBankPUB-01958698

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes, concanavalin A raised thymosin beta‑4 6.3-fold after 1 h of stimulation, without elevation of the mRNA level.
In plain wordsIn rat immune cells in culture, a stimulus raised the cells' own thymosin beta‑4 6.3-fold within 1 hour.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThymosin beta 4 after 1 h of concanavalin A
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Measurements
fold increase
6.3 fold
1 h concanavalin A
Source sentences
Summary
In the presence of concanavalin A a 6.3-fold increase of thymosin beta 4 occurred already after 1 h of stimulation without elevation of the corresponding mRNA level.
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869801
02LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes, the 6.3-fold early increase of thymosin beta‑4 after concanavalin A occurred without elevation of the corresponding mRNA level.
In plain wordsIn rat immune cells in culture, the early rise of natural thymosin beta‑4 came without a rise in its mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeThymosin beta 4 mRNA after 1 h of concanavalin A
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Source sentences
Summary
In the presence of concanavalin A a 6.3-fold increase of thymosin beta 4 occurred already after 1 h of stimulation without elevation of the corresponding mRNA level.
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869802
03LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes during S phase, thymosin beta‑4 increased 2.5-fold with a higher mRNA level, but did not exceed the growth-related increase of total protein.
In plain wordsIn rat immune cells in culture, natural thymosin beta‑4 rose 2.5-fold in a later cell stage, in line with total protein growth.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThymosin beta 4 in S phase
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Measurements
fold increase
2.5 fold
S phase
Source sentences
Summary
In contrast, during the S phase the increase of thymosin beta 4 (2.5-fold) was accompanied by a higher mRNA level, but did not exceed the growth related increase of total protein.
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869803
04LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes, anti-T cell receptor antibody or PMA with A23187 did not lead to a marked increase of thymosin beta‑4 in early G1 phase.
In plain wordsIn rat immune cells in culture, two other stimuli did not raise natural thymosin beta‑4 markedly in the early stage.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeEarly G1 thymosin beta 4 after anti-T cell receptor antibody or PMA with ionophore
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Source sentences
Summary
Stimulation with a crosslinked antibody against rat T cell antigen receptor or stimulation with phorbol 12-myristate 13-acetate (PMA) and Ca(2+)-ionophore A23187, separately or in combination, did not lead to the marked increase of the thymosin beta 4 concentration in the early G1 phase but resulted…
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869804
05LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes, anti-T cell receptor antibody or PMA with A23187 resulted in elevated thymosin beta‑4 peptide and mRNA levels during S phase.
In plain wordsIn rat immune cells in culture, two other stimuli raised natural thymosin beta‑4 and its mRNA in the later cell stage.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseS phase thymosin beta 4 and mRNA after anti-T cell receptor antibody or PMA with ionophore
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Source sentences
Summary
Stimulation with a crosslinked antibody against rat T cell antigen receptor or stimulation with phorbol 12-myristate 13-acetate (PMA) and Ca(2+)-ionophore A23187, separately or in combination, did not lead to the marked increase of the thymosin beta 4 concentration in the early G1 phase but resulted…
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869805
06LabEndogenous levelIn vitro (cells)Mechanism
In rat thymocytes, the protein kinase C inhibitor H-7 did not affect cellular thymosin beta‑4 content 1 h and 48 h after concanavalin A stimulation.
In plain wordsIn rat immune cells in culture, blocking protein kinase C did not change natural thymosin beta‑4 content.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeThymosin beta 4 content after protein kinase C inhibition with H-7
Study
ratn: not reported in source
Stimulated rat thymocytes in culture
Outcome group
Endogenous peptide levels · Immune and inflammation
Source sentences
Summary
This assumption was reinforced by the observation that inhibition of the protein kinase C activity by 1-(5-isoquinolinylsulfony)-2-methylpiperazine (H-7) did not affect the cellular thymosin beta 4 content 1 h and 48 h after concanavalin A (Con A) stimulation.
2 context sentences(design, population, supporting numbers)
Title · context
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Summary · context
The expression of the actin-sequestering peptide, thymosin beta 4, was analyzed in proliferating rat thymocytes, activated by diverse stimuli, during the early G1 phase and the S phase.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0195869806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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