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Study · Non-randomized trial · n = 10 · 1991

8 results

High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine.

Aebi S, Assereto R, Lauterburg BH

European journal of clinical investigation1 Feb 1991Cited by 66 (Europe PMC)

PMID1907548 (opens in a new tab)DOI10.1111/j.1365-2362.1991.tb01366.x (opens in a new tab)PepBankPUB-01907548
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, intravenous glutathione increased plasma total glutathione from 17.5 to 823 mumol l-1.

    In plain wordsIn healthy volunteers, intravenous glutathione raised blood total glutathione from 17.5 to 823 mumol l-1.

    Peptide
    Glutathione
    Outcome
    IncreasePlasma total glutathione
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Plasma total glutathione mean
    17.5 mumol l-1
    Before intravenous glutathione infusion
    Plasma total glutathione SD
    13.4 mumol l-1
    Before intravenous glutathione infusion
    Plasma total glutathione mean
    823 mumol l-1
    After intravenous glutathione infusion
    Plasma total glutathione SD
    326 mumol l-1
    After intravenous glutathione infusion

    Source sentences

    Summary
    Following the intravenous infusion of 2 g m-2 of glutathione the concentration of total glutathione in plasma increased from 17.5 +/- 13.4 mumol l-1 (mean +/- SD) to 823 +/- 326 mumol l-1.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  2. 02HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, exogenous glutathione had a volume of distribution of 176 +/- 107 ml kg-1.

    In plain wordsIn healthy volunteers, glutathione's volume of distribution was 176 +/- 107 ml kg-1.

    Peptide
    Glutathione
    Outcome
    Not applicableVolume of distribution
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Volume of distribution
    176 ml kg-1
    Exogenous glutathione in healthy volunteers
    Volume of distribution reported ± uncertainty (type not stated)
    107 ml kg-1
    Exogenous glutathione in healthy volunteers

    Source sentences

    Summary
    The volume of distribution of exogenous glutathione was 176 +/- 107 ml kg-1 and the elimination rate constant was 0.063 +/- 0.027 min-1 corresponding to a half-life of 14.1 +/- 9.2 min.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  3. 03HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, glutathione's elimination rate constant was 0.063 +/- 0.027 min-1.

    In plain wordsIn healthy volunteers, glutathione's elimination rate constant was 0.063 +/- 0.027 min-1.

    Peptide
    Glutathione
    Outcome
    Not applicableElimination rate constant
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Elimination rate constant
    0.063 min-1
    Exogenous glutathione in healthy volunteers
    Elimination rate constant reported ± uncertainty (type not stated)
    0.027 min-1
    Exogenous glutathione in healthy volunteers

    Source sentences

    Summary
    The volume of distribution of exogenous glutathione was 176 +/- 107 ml kg-1 and the elimination rate constant was 0.063 +/- 0.027 min-1 corresponding to a half-life of 14.1 +/- 9.2 min.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  4. 04HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, glutathione's half-life was 14.1 +/- 9.2 min.

    In plain wordsIn healthy volunteers, glutathione's half-life was 14.1 +/- 9.2 min.

    Peptide
    Glutathione
    Outcome
    Not applicableElimination half-life
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Elimination half-life
    14.1 min
    Exogenous glutathione in healthy volunteers
    Elimination half-life reported ± uncertainty (type not stated)
    9.2 min
    Exogenous glutathione in healthy volunteers

    Source sentences

    Summary
    The volume of distribution of exogenous glutathione was 176 +/- 107 ml kg-1 and the elimination rate constant was 0.063 +/- 0.027 min-1 corresponding to a half-life of 14.1 +/- 9.2 min.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  5. 05HumanNon-randomized trialMechanism

    In healthy volunteers, plasma cysteine increased from 8.9 to 114 mumol l-1 after glutathione infusion.

    In plain wordsIn healthy volunteers, blood cysteine rose from 8.9 to 114 mumol l-1 after glutathione infusion.

    Peptide
    Glutathione
    Outcome
    IncreasePlasma cysteine
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Plasma cysteine
    8.9 mumol l-1
    Before glutathione infusion
    Plasma cysteine reported ± uncertainty (type not stated)
    3.5 mumol l-1
    Before glutathione infusion
    Plasma cysteine
    114 mumol l-1
    After glutathione infusion
    Plasma cysteine reported ± uncertainty (type not stated)
    45 mumol l-1
    After glutathione infusion

    Source sentences

    Summary
    Cysteine in plasma increased from 8.9 +/- 3.5 mumol l-1 to 114 +/- 45 mumol l-1 after the infusion.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  6. 06HumanNon-randomized trialMechanism

    In healthy volunteers, glutathione infusion decreased plasma total cyst(e)ine despite the increase in cysteine.

    In plain wordsIn healthy volunteers, glutathione infusion reduced blood total cyst(e)ine despite increased cysteine.

    Peptide
    Glutathione
    Outcome
    DecreasePlasma total cyst(e)ine
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Source sentences

    Summary
    In spite of the increase in cysteine, the plasma concentration of total cyst(e)ine (i.e. cysteine, cystine, and mixed disulphides) decreased, suggesting an increased uptake of cysteine from plasma into cells.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  7. 07HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, urinary glutathione excretion increased 300-fold in the 90 min after glutathione infusion.

    In plain wordsIn healthy volunteers, urinary glutathione increased 300-fold during the 90 min after infusion.

    Peptide
    Glutathione
    Outcome
    IncreaseUrinary glutathione excretion
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Urinary glutathione excretion increase
    300 fold
    In the 90 min following glutathione infusion

    Source sentences

    Summary
    Urinary excretion of glutathione and of cyst(e)ine was increased 300-fold and 10-fold, respectively, in the 90 min following the infusion.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.
  8. 08HumanNon-randomized trialMechanism

    In healthy volunteers, urinary cyst(e)ine excretion increased 10-fold in the 90 min after glutathione infusion.

    In plain wordsIn healthy volunteers, urinary cyst(e)ine increased 10-fold during the 90 min after glutathione infusion.

    Peptide
    Glutathione
    Outcome
    IncreaseUrinary cyst(e)ine excretion
    Study

    n = 10

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g m-2 · intravenousAs given in this study (human).

    Measurements

    Urinary cyst(e)ine excretion increase
    10 fold
    In the 90 min following glutathione infusion

    Source sentences

    Summary
    Urinary excretion of glutathione and of cyst(e)ine was increased 300-fold and 10-fold, respectively, in the 90 min following the infusion.
    1 context sentence
    Summary · context
    In order to elucidate the underlying mechanisms the kinetics and the effect of glutathione on plasma and urine sulphydryls were studied in 10 healthy volunteers.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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