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Study · Animal study (in vivo) · guinea pigs and rat · 1991

9 results

[Functional morphology of peripheral endocrine glands after thymic polypeptide administration in secondary immunodeficiency].

Khmel'nitskiĭ OK, Brezhneva VA

Arkhiv patologii1 Jan 1991

PMID1859290 (opens in a new tab)PepBankPUB-01859290
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intact immunity, thymalin administration was associated with morphological signs of transient steroidogenic gland inhibition.

    In plain wordsIn rats with intact immunity, thymalin administration showed signs of temporary inhibition of steroid-producing glands.

    Peptide
    Thymalin
    Outcome
    DecreaseSteroidogenic gland function
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Morphological signs of transitory inhibition of steroidogenic gland function and thyroid stimulation were revealed in rats with intact immune system.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intact immunity, thymalin administration was associated with morphological signs of thyroid stimulation.

    In plain wordsIn rats with intact immunity, thymalin administration showed signs of thyroid stimulation.

    Peptide
    Thymalin
    Outcome
    IncreaseThyroid stimulation
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Morphological signs of transitory inhibition of steroidogenic gland function and thyroid stimulation were revealed in rats with intact immune system.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats during thymalin administration, thyroid epithelial hyperplasia accompanied changes in thyroid hormone levels.

    In plain wordsIn rats, thymalin administration was associated with overgrowth of thyroid epithelial tissue.

    Peptide
    Thymalin
    Outcome
    IncreaseThyroid epithelial hyperplasia
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperplastic changes in thyroid epithelium were associated with decreased levels of total T3 and T4 and increased serum level of TTH.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats during thymalin administration, thyroid epithelial hyperplasia was associated with decreased total T3 levels.

    In plain wordsIn rats during thymalin administration, thyroid tissue overgrowth was linked to lower total T3 levels.

    Peptide
    Thymalin
    Outcome
    DecreaseTotal T3 level
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperplastic changes in thyroid epithelium were associated with decreased levels of total T3 and T4 and increased serum level of TTH.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats during thymalin administration, thyroid epithelial hyperplasia was associated with decreased total T4 levels.

    In plain wordsIn rats during thymalin administration, thyroid tissue overgrowth was linked to lower total T4 levels.

    Peptide
    Thymalin
    Outcome
    DecreaseTotal T4 level
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperplastic changes in thyroid epithelium were associated with decreased levels of total T3 and T4 and increased serum level of TTH.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats during thymalin administration, thyroid epithelial hyperplasia was associated with increased serum TTH levels.

    In plain wordsIn rats during thymalin administration, thyroid tissue overgrowth was linked to higher serum TTH levels.

    Peptide
    Thymalin
    Outcome
    IncreaseSerum TTH level
    Study

    Ratsn: not reported in source

    Intact immune system
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperplastic changes in thyroid epithelium were associated with decreased levels of total T3 and T4 and increased serum level of TTH.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized guinea pigs, thymalin administration 45 days after surgery did not correct regressive thyroid parenchymal changes.

    In plain wordsIn guinea pigs after thymus removal, thymalin did not correct regressive thyroid tissue changes.

    Peptide
    Thymalin
    Outcome
    No significant changeRegressive thyroid parenchymal changes
    Study

    Guinea pigsn: not reported in source

    Thymectomy
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Regressive changes in the thyroid parenchyma and hyperplasia of steroid-producing elements of the testis and adrenal cortex in the thymectomized guinea pigs could not be corrected by the thymalin administration 45 days after the operation.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized guinea pigs, thymalin administration 45 days after surgery did not correct hyperplasia of testicular steroid-producing elements.

    In plain wordsIn guinea pigs after thymus removal, thymalin did not correct overgrowth of steroid-producing testicular elements.

    Peptide
    Thymalin
    Outcome
    No significant changeTesticular steroid-producing element hyperplasia
    Study

    Guinea pigsn: not reported in source

    Thymectomy
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Regressive changes in the thyroid parenchyma and hyperplasia of steroid-producing elements of the testis and adrenal cortex in the thymectomized guinea pigs could not be corrected by the thymalin administration 45 days after the operation.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized guinea pigs, thymalin administration 45 days after surgery did not correct hyperplasia of adrenal cortical steroid-producing elements.

    In plain wordsIn guinea pigs after thymus removal, thymalin did not correct overgrowth of steroid-producing adrenal elements.

    Peptide
    Thymalin
    Outcome
    No significant changeAdrenal cortical steroid-producing element hyperplasia
    Study

    Guinea pigsn: not reported in source

    Thymectomy
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Regressive changes in the thyroid parenchyma and hyperplasia of steroid-producing elements of the testis and adrenal cortex in the thymectomized guinea pigs could not be corrected by the thymalin administration 45 days after the operation.
    1 context sentence
    Summary · context
    The state of thyroid, adrenal cortex and testicular endocrine cells during the course of thymalin administration was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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