Glutathione infusion potentiates glucose-induced insulin secretion in aged patients with impaired glucose tolerance.

Paolisso G, Giugliano D, Pizza G, Gambardella A, Tesauro P, Varricchio M, D'Onofrio F

Diabetes care1 Jan 1992Cited by 38 (Europe PMC)

PMID1737525DOI10.2337/diacare.15.1.1PepBankPUB-01737525

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In older subjects with normal glucose tolerance, glutathione infusion did not affect the beta-cell response to glucose.
In plain wordsIn older people with normal glucose tolerance, glutathione infusion did not change the insulin-producing cells' response to glucose.
Peptide
Glutathione
Outcome
No significant changeBeta-cell response with normal glucose tolerance
Study
n = 10
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Source sentences
Summary
In subjects with normal glucose tolerance, glutathione infusion failed to affect beta-cell response to glucose.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Report a problemFND-0173752501
02HumanNon-randomized trialEfficacy outcome
In older patients with impaired glucose tolerance, glutathione significantly potentiated glucose-induced insulin secretion.
In plain wordsIn older people with impaired glucose tolerance, glutathione increased insulin release in response to glucose.
Peptide
Glutathione
Outcome
IncreaseGlucose-induced insulin secretion with IGT
Study
n = 10
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Source sentences
Summary
In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Report a problemFND-0173752502
03HumanNon-randomized trialEfficacy outcome
In older patients with impaired glucose tolerance, glutathione potentiated beta-cell responses at plasma glucose levels between 10 and 15 mM.
In plain wordsIn older people with impaired glucose tolerance, glutathione increased insulin-producing cells' responses at glucose levels between 10 and 15 mM.
Peptide
Glutathione
Outcome
IncreaseBeta-cell response at intermediate glucose levels
Study
n = 10
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Measurements
Plasma glucose levels
10 to 15 mM
IGT patients during hyperglycemic clamps with potentiated beta-cell response
Source sentences
Summary
Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM.
2 context sentences(design, population, supporting numbers)
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Summary · context
Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
Report a problemFND-0173752503
04HumanNon-randomized trialEfficacy outcome
In older patients with impaired glucose tolerance, glutathione's potentiating effect disappeared at plasma glucose levels greater than 15 mM.
In plain wordsIn older people with impaired glucose tolerance, glutathione's effect disappeared when blood glucose exceeded 15 mM.
Peptide
Glutathione
Outcome
No significant changeBeta-cell response at high glucose levels
Study
n = 10
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Measurements
Plasma glucose threshold for disappearance of beta-cell potentiation
> 15 mM
Patients with IGT during hyperglycemic clamps
Source sentences
Summary
This effect disappeared at plasma glucose levels greater than 15 mM.
3 context sentences(design, population, supporting numbers)
Summary · context
Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM.
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Summary · context
Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
Report a problemFND-0173752504
05HumanNon-randomized trialMechanism
In the studied older subjects, glutathione did not affect insulin clearance.
In plain wordsIn the studied older people, glutathione did not change insulin removal.
Peptide
Glutathione
Outcome
No significant changeInsulin clearance
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Source sentences
Summary
No effect of glutathione on insulin clearance and action was observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Report a problemFND-0173752505
06HumanNon-randomized trialEfficacy outcome
In the studied older subjects, glutathione did not affect insulin action.
In plain wordsIn the studied older people, glutathione did not change insulin action.
Peptide
Glutathione
Outcome
No significant changeInsulin action
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg/min · infusionAs given in this study (human).
Source sentences
Summary
No effect of glutathione on insulin clearance and action was observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions
Report a problemFND-0173752506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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