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Study · Measured the body's own peptide · 1991

2 results

Effects of PCB (Aroclor 1254) on non-specific immune parameters in rhesus (Macaca mulatta) monkeys.

Tryphonas H, Luster MI, White KL Jr, Naylor PH, Erdos MR, Burleson GR, Germolec D, Hodgen M, Hayward S, Arnold DL

International journal of immunopharmacology1 Jan 1991Cited by 35 (Europe PMC)

PMID1721612 (opens in a new tab)DOI10.1016/0192-0561(91)90176-8 (opens in a new tab)PepBankPUB-01721612
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In female rhesus monkeys chronically exposed to PCB, natural thymosin alpha‑1 levels showed a statistically significant dose-related increase.

    In plain wordsIn female rhesus monkeys exposed to PCB, the body's own thymosin alpha‑1 levels rose with higher PCB doses.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThymosin alpha-1 levels
    Study

    rhesus monkeyn: not reported in source

    Comparator
    Control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Similarly, a statistically significant dose-related increase was noted for thymosin alpha-1 levels but not for thymosin beta-4 levels.
    2 context sentences
    Summary · context
    The effects of low level, chronic polychlorinated biphenyl--Aroclor 1254--(PCB) exposure were investigated on non-specific immune parameters in female rhesus (Macaca mulatta) monkeys.
    Summary · context
    Five groups of monkeys were orally administered with PCB at concentrations of 0, 5, 20, 40 or 80 micrograms/kg bw/day.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In female rhesus monkeys chronically exposed to PCB (Aroclor 1254), the body's own thymosin beta‑4 level showed no dose-related increase.

    In plain wordsIn monkeys exposed to PCB, natural thymosin beta‑4 levels did not rise with the PCB dose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta-4 level after PCB exposure
    Study

    rhesus macaquen: not reported in source

    Comparator
    Control group (0 micrograms/kg bw/day)
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Similarly, a statistically significant dose-related increase was noted for thymosin alpha-1 levels but not for thymosin beta-4 levels.
    1 context sentence
    Summary · context
    Five groups of monkeys were orally administered with PCB at concentrations of 0, 5, 20, 40 or 80 micrograms/kg bw/day.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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