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Study · Measured the body's own peptide · 1991

6 results

Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.

Schöbitz B, Netzker R, Hannappel E, Brand K

European journal of biochemistry1 Jul 1991Cited by 27 (Europe PMC)

PMID1712726 (opens in a new tab)DOI10.1111/j.1432-1033.1991.tb16118.x (opens in a new tab)PepBankPUB-01712726
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In concanavalin-A-stimulated rat thymocytes, the cell's own thymosin beta‑4 showed an early, transient 10-fold increase 1 h after stimulation.

    In plain wordsIn rat immune cells in culture, the cells' own thymosin beta‑4 rose 10-fold within 1 hour of stimulation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta 4 content 1 h after stimulation
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Measurements

    fold increase
    10 fold
    1 h after stimulation

    Source sentences

    Summary
    An early, transient 10-fold increase of the peptide occurred 1 h after stimulation without elevation of the corresponding mRNA level.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In concanavalin-A-stimulated rat thymocytes, the early increase of thymosin beta‑4 occurred without elevation of the corresponding mRNA level.

    In plain wordsIn rat immune cells in culture, the early rise of natural thymosin beta‑4 came without a rise in its mRNA.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta 4 mRNA at 1 h after stimulation
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    An early, transient 10-fold increase of the peptide occurred 1 h after stimulation without elevation of the corresponding mRNA level.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In rat thymocytes, the early increase of thymosin beta‑4 coincided with an increase of thymosin beta‑4 biosynthesis.

    In plain wordsIn rat immune cells in culture, the early rise of natural thymosin beta‑4 matched a rise in its production.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta 4 biosynthesis during the early increase
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    This increase coincided with that of thymosin beta 4 biosynthesis.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In rat thymocytes, the sharp decline of thymosin beta‑4 content was not due to secretion of the peptide into the medium.

    In plain wordsIn rat immune cells in culture, the later fall in natural thymosin beta‑4 was not caused by release into the medium.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeSecretion of thymosin beta 4 into the medium
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    The sharp decline of the thymosin beta 4 content was not due to a secretion of the peptide into the medium.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In rat thymocytes during S phase and mitosis, thymosin beta‑4 biosynthetic rates and mRNA content increased again, but the cellular concentration did not.

    In plain wordsIn rat immune cells in culture, thymosin beta‑4 production and mRNA rose again in later cell stages, but its level in cells did not.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedThymosin beta 4 biosynthesis and mRNA in S phase and mitosis
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    During S phase and mitosis, the biosynthetic rates as well as mRNA content, but not the cellular thymosin beta 4 concentration, increased again.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  6. 06LabEndogenous levelIn vitro (cells)Mechanism

    In rat thymocytes, thymosin beta‑4 values returned to those of quiescent cells after 96 h of culture.

    In plain wordsIn rat immune cells in culture, natural thymosin beta‑4 values went back to those of resting cells after 96 hours.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta 4 values after 96 h of culture
    Study

    ratn: not reported in source

    Concanavalin-A-stimulated rat thymocytes in culture
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    After 96 h of culture the values returned to those of quiescent cells.
    2 context sentences
    Title · context
    Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
    Summary · context
    The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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