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Study · Measured the body's own peptide · 1991

2 results

The gonadotropin-releasing hormone agonist leuprolide affects the thymus and other non-reproductive systems of female rats.

Blacker CM, Ataya KM, Savoy-Moore RT, Subramanian MG, Mutchnick MG, Dunbar JC

Acta endocrinologica1 Nov 1991Cited by 16 (Europe PMC)

PMID1661999 (opens in a new tab)DOI10.1530/acta.0.1250581 (opens in a new tab)PepBankPUB-01661999
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In leuprolide-treated ovariectomized rats, natural thymosin alpha‑1 levels increased, while thymosin beta 4 did not.

    In plain wordsIn rats given leuprolide after ovary removal, the body's own thymosin alpha‑1 levels rose.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThymosin alpha 1 in leuprolide-treated ovariectomized rats
    Study

    ratn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Thymosin alpha 1, but not thymosin beta 4, increased in leuprolide-treated ovariectomized rats.
    2 context sentences
    Summary · context
    To evaluate the effects of a gonadotropin-releasing hormone agonist on non-reproductive systems, we administered [D-Leu6,Des-gly10]-GnRH ethylamide (leuprolide; 5 micrograms/day) for 21 days to female Sprague-Dawley rats.
    Summary · context
    In Experiment 2, intact and ovariectomized rats were implanted with minipumps delivering leuprolide or 0.9% NaCl.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In leuprolide-treated ovariectomized female rats, the body's own thymosin beta‑4 level did not increase.

    In plain wordsIn rats given leuprolide after ovary removal, natural thymosin beta‑4 levels did not rise.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta 4 level in ovariectomized rats on leuprolide
    Study

    ratn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Thymosin alpha 1, but not thymosin beta 4, increased in leuprolide-treated ovariectomized rats.
    1 context sentence
    Summary · context
    In Experiment 2, intact and ovariectomized rats were implanted with minipumps delivering leuprolide or 0.9% NaCl.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 5Current

    27 Oct 2026, 16:37 UTC

    The same notice was added 2 times, first on 12 Oct 2026, 18:17 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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