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Study · Animal study (in vivo) · guinea pig · 1991

4 results

[Effect of thymagen, thymalin and vilosen on the cAMP and cGMP levels and phosphodiesterase activity in spleen lymphocytes during sensitization and anaphylactic shock].

Demidov SV, Kostromin AN, Kuĭbeda VV, Chernaia IV, Borovok MI

Ukrainskii biokhimicheskii zhurnal (1978)1 Jul 1991

PMID1659006 (opens in a new tab)PepBankPUB-01659006
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In sensitized guinea pigs, thymogen increased cyclic nucleotide catabolic enzyme activity in lymphocytes.

    In plain wordsIn guinea pigs with sensitization, thymogen increased lymphocyte enzyme activity involved in cyclic nucleotide breakdown.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseCyclic nucleotide catabolic enzyme activity during sensitization
    Study

    guinea pign: not reported in source

    Sensitized guinea pigs
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.
    1 context sentence
    Summary · context
    The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anaphylaxis-treated animals, thymogen tended to increase cyclic nucleotide catabolic enzyme activity in lymphocytes.

    In plain wordsIn animals with anaphylaxis, thymogen tended to increase lymphocyte enzyme activity involved in cyclic nucleotide breakdown.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseCyclic nucleotide catabolic enzyme activity during anaphylaxis
    Study

    guinea pign: not reported in source

    Anaphylaxis-treated animals
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.
    1 context sentence
    Summary · context
    The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization.

Studies that did not test the peptide alone2

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

  1. 03AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism

    In sensitized guinea pigs, pooled thymogen, thymalin and vilosen increased cyclic nucleotide catabolism enzyme activity in lymphocytes.

    In plain wordsIn sensitized guinea pigs, pooled thymogen, thymalin and vilosen increased lymphocyte enzyme activity for cyclic nucleotide breakdown.

    Peptide
    Thymalin
    Outcome
    IncreaseCyclic nucleotide catabolism enzyme activity during sensitization
    Study

    guinea pign: not reported in source

    Sensitized guinea pigs
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs
    1 context sentence
    Summary · context
    The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  2. 04AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism

    In animals with anaphylaxis, pooled thymogen, thymalin and vilosen tended to increase cyclic nucleotide catabolism enzyme activity in lymphocytes.

    In plain wordsIn animals with anaphylaxis, pooled thymogen, thymalin and vilosen tended to increase lymphocyte enzyme activity for cyclic nucleotide breakdown.

    Peptide
    Thymalin
    Outcome
    IncreaseCyclic nucleotide catabolism enzyme activity during anaphylaxis
    Study

    guinea pign: not reported in source

    Animals with anaphylaxis
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.
    1 context sentence
    Summary · context
    The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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