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Study · Animal study (in vivo) · rat · 1991

3 results

Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection.

Potaman VN, Antonova LV, Dubynin VA, Zaitzev DA, Kamensky AA, Myasoedov NF, Nezavibatko VN

Neuroscience letters1 Jun 1991Cited by 25 (Europe PMC)

PMID1652713 (opens in a new tab)DOI10.1016/0304-3940(91)90912-d (opens in a new tab)PepBankPUB-01652713
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, the labelled peptide was detected in brain extracts at two time points after intravenous injection.

    In plain wordsIn rats, the injected labelled peptide was found in brain extracts at two time points.

    Peptide
    Semax
    Outcome
    Not applicableDetection of labelled peptide in brain extracts
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    At two time points the labelled peptide was detected in brain extracts.
    1 context sentence
    Summary · context
    Rat blood and brain extracts after intravenous injection of the tritiated synthetic ACTH(4-10) analogue, Met-Glu-His-Phe-Pro-Gly-Pro, were subjected to a high-performance liquid chromatographic analysis.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, brain-to-blood ratios of the peptide were significantly higher than those for labelled bovine serum albumin.

    In plain wordsIn rats, more of the peptide reached the brain relative to blood than for albumin.

    Peptide
    Semax
    Outcome
    IncreaseBrain-to-blood ratio versus labelled albumin
    Study

    ratn: not reported in source

    Comparator
    Labelled bovine serum albumin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    The brain to blood ratios of peptide content in brain and blood were found to be significantly higher than those calculated for a distribution of labelled bovine serum albumin in rat brain capillaries and blood.
    1 context sentence
    Summary · context
    Rat blood and brain extracts after intravenous injection of the tritiated synthetic ACTH(4-10) analogue, Met-Glu-His-Phe-Pro-Gly-Pro, were subjected to a high-performance liquid chromatographic analysis.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, the quantity of peptide in brain tissue did not exceed 0.01% of the injected dose.

    In plain wordsIn rats, no more than 0.01% of the injected dose of the peptide reached the brain.

    Peptide
    Semax
    Outcome
    Not applicablePeptide quantity in brain tissue
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    Brain peptide quantity
    ≤ 0.01 % of dose injected
    brain tissue

    Source sentences

    Summary
    This strongly suggests that this peptide penetrates into the brain tissues, its quantity not exceeding 0.01% of dose injected.
    1 context sentence
    Summary · context
    Rat blood and brain extracts after intravenous injection of the tritiated synthetic ACTH(4-10) analogue, Met-Glu-His-Phe-Pro-Gly-Pro, were subjected to a high-performance liquid chromatographic analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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