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Study · Measured the body's own peptide · 1992

3 results

Characterization of thymic weight and thymic peptide thymosin-beta 4: effects of hypophysectomy, sex, and neonatal sexual differentiation.

Wise T, MacDonald GJ, Klindt J, Ford JJ

Thymus1 Jun 1992Cited by 8 (Europe PMC)

PMID1626338 (opens in a new tab)PepBankPUB-01626338
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, thymosin beta‑4 concentrations decreased with time after hypophysectomy and were reduced by 50% at 30 days.

    In plain wordsIn rats, the body's own thymosin beta‑4 fell after removal of the pituitary gland and was down by 50% at 30 days.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin-beta 4 concentration after hypophysectomy over time
    Study

    ratn: not reported in source

    Hypophysectomized and neonatally manipulated rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    reduction
    50%
    30 days post hypophysectomy

    Source sentences

    Summary
    After hypophysectomy, thymic weight and thymosin-beta 4 concentrations decreased with time (5, 10, 15, and 30 days post hypophysectomy) and by 30 days post hypophysectomy were reduced by 50%.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats 17 days after hypophysectomy, serum thymosin beta‑4 concentrations were higher across all treatments.

    In plain wordsIn rats 17 days after pituitary removal, blood levels of the body's own thymosin beta‑4 were higher across all treatment groups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin-beta 4 concentration in hypophysectomized rats across treatments
    Study

    ratn: not reported in source

    Hypophysectomized and neonatally manipulated rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Hypophysectomy did produce increased thymosin-beta 4 concentrations across all treatments (p less than 0.01)
    1 context sentence
    Summary · context
    Serum was collected for thymosin-beta 4 analysis.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In hypophysectomized rats, males and Day-2 castrate males had higher thymosin beta‑4 concentrations than hypophysectomized females and neonatally androgenized females.

    In plain wordsIn rats without a pituitary gland, males and early-castrated males had higher levels of the body's own thymosin beta‑4 than females.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin-beta 4 concentration by sex and neonatal differentiation
    Study

    ratn: not reported in source

    Hypophysectomized and neonatally manipulated rats
    Comparator
    Hypophysectomized females and neonatally androgenized females
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Hypophysectomized males and Day-2 castrate males had increased thymosin-beta 4 concentrations when compared to hypophysectomized females and neonatally androgenized females (p less than 0.05).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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