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Study · In vitro (cells) · 1992

2 results

Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.

Sanders MC, Goldstein AL, Wang YL

Proceedings of the National Academy of Sciences of the United States of America1 May 1992Cited by 118 (Europe PMC)

PMID1584803 (opens in a new tab)PMCIDPMC49146 (opens in a new tab)DOI10.1073/pnas.89.10.4678 (opens in a new tab)PepBankPUB-01584803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In living epithelial cells and fibroblasts, microinjection of synthetic thymosin beta‑4 reduced stress fibers.

    In plain wordsIn cells, injecting thymosin beta‑4 reduced the number of stress fibers.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseStress fibers after thymosin beta 4 microinjection
    Study

    n: not reported in source

    Living epithelial cells and fibroblasts
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · microinjectionAs given in this study.

    Source sentences

    Summary
    The injection induced a diminution of stress fibers and a dose-dependent depolymerization of actin filaments as indicated by quantitative image analysis of phalloidin binding.
    1 context sentence
    Summary · context
    To examine this potential function, we have increased the cellular beta 4 concentration by microinjecting synthetic beta 4 into living epithelial cells and fibroblasts.
  2. 02LabIn vitro (cells)Activity measurement

    In living epithelial cells and fibroblasts, microinjection of synthetic thymosin beta‑4 caused dose-dependent depolymerization of actin filaments.

    In plain wordsIn cells, injecting thymosin beta‑4 broke down actin filaments, and more peptide caused more breakdown.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseActin filament depolymerization after thymosin beta 4 microinjection
    Study

    n: not reported in source

    Living epithelial cells and fibroblasts
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · microinjectionAs given in this study.

    Source sentences

    Summary
    The injection induced a diminution of stress fibers and a dose-dependent depolymerization of actin filaments as indicated by quantitative image analysis of phalloidin binding.
    1 context sentence
    Summary · context
    To examine this potential function, we have increased the cellular beta 4 concentration by microinjecting synthetic beta 4 into living epithelial cells and fibroblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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