Desmopressin for bed wetting: length of treatment, vasopressin secretion, and response.

Evans JH, Meadow SR

Archives of disease in childhood1 Feb 1992Cited by 36 (Europe PMC)

PMID1543376PMCIDPMC1793412DOI10.1136/adc.67.2.184PepBankPUB-01543376

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, outcomes did not differ significantly between three-month and one-month desmopressin courses.
In plain wordsIn children with bedwetting, outcomes did not differ significantly between three-month and one-month desmopressin courses.
Peptide
Desmopressin
Outcome
No significant changeResponse by treatment duration
Study
n = 55
Comparator
One month of desmopressin
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · three monthsAs given in this study (human).
Source sentences
Summary
There was no significant difference in outcome between the two groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337601
02HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, 36% improved by at least two dry nights/week during desmopressin treatment.
In plain wordsIn children with bedwetting, 36% improved by at least two dry nights/week during desmopressin treatment.
Peptide
Desmopressin
Outcome
IncreaseImprovement by at least two dry nights per week
Study
n = 55
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · one or three monthsAs given in this study (human).
Measurements
Improved by at least two dry nights/week
36%
overall
Source sentences
Summary
Overall 36% improved by at least two dry nights/week during treatment, but only five children (18%) in the one month group and three (11%) in the three month group became completely dry and only one in each group remained dry after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337602
03HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, five children (18%) became completely dry during one month of desmopressin.
In plain wordsIn children with bedwetting, five children (18%) became completely dry during one month of desmopressin.
Peptide
Desmopressin
Outcome
Not applicableComplete dryness during one-month treatment
Study
n: not reported in source
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · one monthAs given in this study (human).
Measurements
Completely dry
5 children
one month
Completely dry
18%
one month
Source sentences
Summary
Overall 36% improved by at least two dry nights/week during treatment, but only five children (18%) in the one month group and three (11%) in the three month group became completely dry and only one in each group remained dry after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337603
04HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, three children (11%) became completely dry during three months of desmopressin.
In plain wordsIn children with bedwetting, three children (11%) became completely dry during three months of desmopressin.
Peptide
Desmopressin
Outcome
Not applicableComplete dryness during three-month treatment
Study
n: not reported in source
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · three monthsAs given in this study (human).
Measurements
Completely dry
3 children
three months
Completely dry
11%
three months
Source sentences
Summary
Overall 36% improved by at least two dry nights/week during treatment, but only five children (18%) in the one month group and three (11%) in the three month group became completely dry and only one in each group remained dry after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337604
05HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, only one child remained dry after the one-month desmopressin course.
In plain wordsIn children with bedwetting, only one child remained dry after the one-month desmopressin course.
Peptide
Desmopressin
Outcome
Not applicableSustained dryness after one-month treatment
Study
n: not reported in source
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · one monthAs given in this study (human).
Measurements
Remained dry
1 child
one-month group after treatment
Source sentences
Summary
Overall 36% improved by at least two dry nights/week during treatment, but only five children (18%) in the one month group and three (11%) in the three month group became completely dry and only one in each group remained dry after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337605
06HumanNon-randomized trialEfficacy outcome
In children with nocturnal enuresis, only one child remained dry after the three-month desmopressin course.
In plain wordsIn children with bedwetting, only one child remained dry after the three-month desmopressin course.
Peptide
Desmopressin
Outcome
Not applicableSustained dryness after three-month treatment
Study
n: not reported in source
Outcome group
Urinary Continence · Kidney and urinary
Studied dose
Dose not stated · intranasal · three monthsAs given in this study (human).
Measurements
Remained dry
1 child
three-month group after treatment
Source sentences
Summary
Overall 36% improved by at least two dry nights/week during treatment, but only five children (18%) in the one month group and three (11%) in the three month group became completely dry and only one in each group remained dry after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Fifty five children with nocturnal enuresis referred to a hospital enuresis clinic entered a controlled trial to compare the efficacy of one month and three month courses of intranasal desmopressin (Desmospray).
Report a problemFND-0154337606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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