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Study · Animal study (in vivo) · rat · 1992

6 results

[Effect of carnosine and 4-methyluracil on the development of experimental hepatitis in rats].

Silaeva SA, Golenchenko VA, Gavril'chak AV, Onufriev MV, Khatsernova BI, Guliaeva NV, Shekhter AB

Biokhimiia (Moscow, Russia)1 Sept 1992

PMID1467355 (opens in a new tab)PepBankPUB-01467355
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hepatitis, serum ALT during carnosine treatment approximated intact values while untreated levels remained elevated by day 10.

    In plain wordsIn rats with hepatitis, carnosine-treated ALT levels approached normal values while untreated levels remained elevated.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum ALT
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    untreated animals
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was found that by day 10 of experimental hepatitis ALT and histidase levels in blood sera of untreated animals exceeded the normal values 1.3- and 3.9-fold, whereas those in the carnosine-treated group approximated the values characteristic of intact animals.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hepatitis, serum histidase during carnosine treatment approximated intact values while untreated levels remained elevated by day 10.

    In plain wordsIn rats with hepatitis, carnosine-treated histidase levels approached normal values while untreated levels remained elevated.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum histidase
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    untreated animals
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was found that by day 10 of experimental hepatitis ALT and histidase levels in blood sera of untreated animals exceeded the normal values 1.3- and 3.9-fold, whereas those in the carnosine-treated group approximated the values characteristic of intact animals.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with hepatitis, carnosine inhibited liver TBA-active product formation to approximately the same degree as 4-methyluracil.

    In plain wordsIn rats with hepatitis, carnosine reduced liver oxidation products approximately as much as 4-methyluracil.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedLiver TBA-active products
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    4-methyluracil
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine and 4-methyluracil inhibited (in approximately the same degree) the formation of TBA-active products in the liver.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hepatitis, carnosine enhanced parenchymatous tissue regeneration more than other drugs.

    In plain wordsIn rats with hepatitis, carnosine improved liver parenchymal repair more than other drugs.

    Peptide
    L-carnosine
    Outcome
    IncreaseParenchymatous tissue regeneration
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    other drugs
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine enhanced regenerative processes in parenchymatous and connective tissues in a far greater degree in comparison with other drugs.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hepatitis, carnosine enhanced connective tissue regeneration more than other drugs.

    In plain wordsIn rats with hepatitis, carnosine improved connective tissue repair more than other drugs.

    Peptide
    L-carnosine
    Outcome
    IncreaseConnective tissue regeneration
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    other drugs
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine enhanced regenerative processes in parenchymatous and connective tissues in a far greater degree in comparison with other drugs.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with hepatitis, the mitotic index with carnosine exceeded that in untreated animals more than twofold.

    In plain wordsIn rats with hepatitis, liver cell division was greater with carnosine than without treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitotic index
    Study

    ratn: not reported in source

    CCl4-induced acute toxic hepatitis
    Comparator
    untreated animals
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitotic index in the carnosine-treated group exceeded more than twofold the corresponding parameters in untreated animals.
    1 context sentence
    Summary · context
    A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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