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Study · Non-randomized trial · n = 12 · 1992

7 results

Pituitary and ovarian suppression after early follicular and mid-luteal administration of a LHRH agonist in a depot formulation: decapeptyl CR.

Broekmans FJ, Bernardus RE, Berkhout G, Schoemaker J

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1 Sept 1992Cited by 30 (Europe PMC)

PMID1442160 (opens in a new tab)DOI10.3109/09513599209015549 (opens in a new tab)PepBankPUB-01442160
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normally cycling women, LH peaked within 48 hours after triptorelin and declined to hypogonadotropic levels within two weeks.

    In plain wordsIn women, LH peaked within 48 hours after triptorelin and declined to low levels within two weeks.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedInitial LH response
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luteinizing hormone (LH) and follicle stimulating hormone (FSH) rose to peak values within 48 h, and declined to hypogonadotropic levels within 2 weeks' time.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normally cycling women, FSH peaked within 48 hours after triptorelin and declined to hypogonadotropic levels within two weeks.

    In plain wordsIn women, FSH peaked within 48 hours after triptorelin and declined to low levels within two weeks.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedInitial FSH response
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luteinizing hormone (LH) and follicle stimulating hormone (FSH) rose to peak values within 48 h, and declined to hypogonadotropic levels within 2 weeks' time.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normally cycling women, steroid levels initially rose after triptorelin and fell to hypogonadal values within one week.

    In plain wordsIn women, steroid levels initially rose after triptorelin and fell to low values within one week.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedSteroid response
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Steroid levels showed a slight to marked rise after injection and fell to hypogonadal values within 1 week.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normally cycling women, LH suppression persisted until the eighth week after triptorelin injection.

    In plain wordsIn women, LH suppression persisted until the eighth week after triptorelin injection.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSustained LH suppression
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LH suppression was maintained until the 8th week after the injection, while FSH levels rose to normal between the 3rd and 4th week.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  5. 05HumanNon-randomized trialEfficacy outcome

    In normally cycling women, FSH returned to normal between the third and fourth week after triptorelin injection.

    In plain wordsIn women, FSH returned to normal between the third and fourth week after triptorelin injection.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFSH recovery
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LH suppression was maintained until the 8th week after the injection, while FSH levels rose to normal between the 3rd and 4th week.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  6. 06HumanNon-randomized trialEfficacy outcome

    In normally cycling women, estrogen secretion began to recover during the seventh and eighth week after triptorelin injection.

    In plain wordsIn women, estrogen secretion began to recover during the seventh and eighth week after triptorelin injection.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseEstrogen secretion recovery
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Estrogen secretion started to be restored in the course of the 7th and 8th week.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.
  7. 07HumanNon-randomized trialEfficacy outcome

    In normally cycling women, menses occurred between the eleventh and thirteenth week after triptorelin injection.

    In plain wordsIn women, menses occurred between the eleventh and thirteenth week after triptorelin injection.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableTime to menses
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Menses occurred between the 11th and 13th week after the injection of the drug.
    1 context sentence
    Summary · context
    In order to study its effect on pituitary and ovarian function, a single dose of triptorelin depot (Decapeptyl CR, Ferring) was administered to 12 women in the early follicular (EF,n = 6) or mid-luteal phase (ML,n = 6) of a normal cycle.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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