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Study · Non-randomized trial · n = 10 · 1992

6 results

Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics.

Paolisso G, Di Maro G, Pizza G, D'Amore A, Sgambato S, Tesauro P, Varricchio M, D'Onofrio F

The American journal of physiology1 Sept 1992Cited by 71 (Europe PMC)

PMID1415522 (opens in a new tab)DOI10.1152/ajpendo.1992.263.3.e435 (opens in a new tab)PepBankPUB-01415522
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy subjects, the increased plasma GSH/GSSG ratio after glutathione infusion improved total body glucose disposal.

    In plain wordsIn healthy subjects, glucose disposal improved after glutathione infusion as the blood GSH/GSSG ratio rose.

    Peptide
    Glutathione
    Outcome
    IncreaseTotal body glucose disposal in healthy subjects
    Study

    n = 10

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    15 mg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    The rise in the plasma GSH/GSSG ratio significantly improved total body glucose disposal in healthy subjects and in diabetic patients.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with diabetes, the increased plasma GSH/GSSG ratio after glutathione infusion improved total body glucose disposal.

    In plain wordsIn patients with diabetes, glucose disposal improved after glutathione infusion as the blood GSH/GSSG ratio rose.

    Peptide
    Glutathione
    Outcome
    IncreaseTotal body glucose disposal in diabetes
    Study

    n = 10

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    15 mg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    The rise in the plasma GSH/GSSG ratio significantly improved total body glucose disposal in healthy subjects and in diabetic patients.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with diabetes, glutathione infusion slightly potentiated the beta-cell response to glucose.

    In plain wordsIn patients with diabetes, glutathione infusion slightly increased the insulin-producing cells' response to glucose.

    Peptide
    Glutathione
    Outcome
    IncreaseBeta-cell response
    Study

    n = 10

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    15 mg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    In this latter group, GSH infusion potentiated the beta-cell response to glucose slightly.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.
  4. 04HumanNon-randomized trialMechanism

    After glutathione infusion, metabolic and hormonal changes correlated with a significant decline in plasma membrane microviscosity.

    In plain wordsAfter glutathione infusion, metabolic and hormonal changes were linked to lower plasma membrane viscosity.

    Peptide
    Glutathione
    Outcome
    DecreasePlasma membrane microviscosity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    15 mg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    After glutathione infusion, all metabolic and hormonal changes correlated with a significant decline in plasma membrane microviscosity.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.

Studies that did not test the peptide alone2

In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Glutathione.

  1. 05HumanNot a test of Glutathione aloneNon-randomized trialEfficacy outcome

    In controls and patients with diabetes, insulin infusion with an increased GSH/GSSG ratio enhanced nonoxidative glucose disposal.

    In plain wordsIn controls and patients with diabetes, insulin infusion with a higher GSH/GSSG ratio increased glucose disposal without oxidation.

    Peptide
    Glutathione
    Outcome
    IncreaseNonoxidative glucose disposal
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    In controls and diabetics, insulin infusion with a simultaneous increase in the plasma GSH/GSSG ratio significantly enhanced nonoxidative glucose disposal without affecting oxidative glucose metabolism.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.

    In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.

  2. 06HumanNot a test of Glutathione aloneNon-randomized trialEfficacy outcome

    In controls and patients with diabetes, insulin infusion with an increased GSH/GSSG ratio did not affect oxidative glucose metabolism.

    In plain wordsIn controls and patients with diabetes, insulin infusion with a higher GSH/GSSG ratio did not change glucose oxidation.

    Peptide
    Glutathione
    Outcome
    No significant changeOxidative glucose metabolism
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    In controls and diabetics, insulin infusion with a simultaneous increase in the plasma GSH/GSSG ratio significantly enhanced nonoxidative glucose disposal without affecting oxidative glucose metabolism.
    2 context sentences
    Summary · context
    In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10)
    Summary · context
    we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio.

    In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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