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Study · Non-randomized trial · n = 7 · 1992

3 results

The systemic availability of oral glutathione.

Witschi A, Reddy S, Stofer B, Lauterburg BH

European journal of clinical pharmacology1 Jan 1992Cited by 159 (Europe PMC)

PMID1362956 (opens in a new tab)DOI10.1007/bf02284971 (opens in a new tab)PepBankPUB-01362956
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In healthy volunteers, oral glutathione did not significantly increase plasma glutathione.

    In plain wordsOral glutathione did not significantly raise blood glutathione in healthy volunteers.

    Peptide
    Glutathione
    Outcome
    No significant changePlasma glutathione
    Study

    n = 7

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.15 mmol.kg-1 · oral · 270 minAs given in this study (human).

    Measurements

    Basal plasma glutathione concentration
    6.2 mumol.l-1
    Baseline before oral glutathione

    Source sentences

    Summary
    During the 270 min after the administration of glutathione in a dose of 0.15 mmol.kg-1 the concentrations of glutathione, cysteine, and glutamate in plasma did not increase significantly, suggesting that the systemic availability of glutathione is negligible in man.
    2 context sentences
    Summary · context
    To assess the feasibility of supplementing oral glutathione we have determined the systemic availability of glutathione in 7 healthy volunteers.
    Summary · context
    The basal concentrations of glutathione, cysteine, and glutamate in plasma were 6.2, 8.3, and 54 mumol.l-1 respectively.
  2. 02HumanNon-randomized trialMechanism

    In healthy volunteers, oral glutathione did not significantly increase plasma cysteine.

    In plain wordsOral glutathione did not significantly raise blood cysteine in healthy volunteers.

    Peptide
    Glutathione
    Outcome
    No significant changePlasma cysteine
    Study

    n = 7

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.15 mmol.kg-1 · oral · 270 minAs given in this study (human).

    Measurements

    Basal plasma cysteine concentration
    8.3 mumol.l-1
    Baseline before oral glutathione

    Source sentences

    Summary
    During the 270 min after the administration of glutathione in a dose of 0.15 mmol.kg-1 the concentrations of glutathione, cysteine, and glutamate in plasma did not increase significantly, suggesting that the systemic availability of glutathione is negligible in man.
    2 context sentences
    Summary · context
    To assess the feasibility of supplementing oral glutathione we have determined the systemic availability of glutathione in 7 healthy volunteers.
    Summary · context
    The basal concentrations of glutathione, cysteine, and glutamate in plasma were 6.2, 8.3, and 54 mumol.l-1 respectively.
  3. 03HumanNon-randomized trialMechanism

    In healthy volunteers, oral glutathione did not significantly increase plasma glutamate.

    In plain wordsOral glutathione did not significantly raise blood glutamate in healthy volunteers.

    Peptide
    Glutathione
    Outcome
    No significant changePlasma glutamate
    Study

    n = 7

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.15 mmol.kg-1 · oral · 270 minAs given in this study (human).

    Measurements

    Basal plasma glutamate concentration
    54 mumol.l-1
    Baseline before oral glutathione

    Source sentences

    Summary
    During the 270 min after the administration of glutathione in a dose of 0.15 mmol.kg-1 the concentrations of glutathione, cysteine, and glutamate in plasma did not increase significantly, suggesting that the systemic availability of glutathione is negligible in man.
    2 context sentences
    Summary · context
    To assess the feasibility of supplementing oral glutathione we have determined the systemic availability of glutathione in 7 healthy volunteers.
    Summary · context
    The basal concentrations of glutathione, cysteine, and glutamate in plasma were 6.2, 8.3, and 54 mumol.l-1 respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT02324426

CNS Uptake of Intranasal Glutathione

University of Washingtonn = 15Dec 2014 to Mar 2015

Parkinson's Disease

Trial pageClinicalTrials.govUpdated 30 Apr 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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