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Study · Animal study (in vivo) · calf and rabbit · 1992

7 results

Adrenocorticotrophic hormone fails to alter plasma fibrinogen and fibronectin values in calves but does so in rabbits.

Gentry PA, Liptrap RM, Tremblay RR, Lichen L, Ross ML

Veterinary research communications1 Jan 1992Cited by 2 (Europe PMC)

PMID1334608 (opens in a new tab)DOI10.1007/bf01839324 (opens in a new tab)PepBankPUB-01334608
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In calves, ACTHAR Gel did not alter circulating fibrinogen.

    In plain wordsIn calves, ACTHAR Gel did not change circulating fibrinogen.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeCirculating fibrinogen
    Study

    calfn: not reported in source

    Calves
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intramuscularAs given in this study (calf).

    Source sentences

    Summary
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel), failed to induce any alteration in circulating fibrinogen or fibronectin values, despite marked elevations in plasma cortisol concentrations.
    1 context sentence
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In calves, ACTHAR Gel did not alter circulating fibronectin.

    In plain wordsIn calves, ACTHAR Gel did not change circulating fibronectin.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeCirculating fibronectin
    Study

    calfn: not reported in source

    Calves
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intramuscularAs given in this study (calf).

    Source sentences

    Summary
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel), failed to induce any alteration in circulating fibrinogen or fibronectin values, despite marked elevations in plasma cortisol concentrations.
    1 context sentence
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In calves, longer-acting ACTHAR Gel elevated plasma cortisol for at least 12 h after treatment.

    In plain wordsIn calves, ACTHAR Gel increased blood cortisol for at least 12 h.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreasePlasma cortisol
    Study

    calfn: not reported in source

    Calves
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscularAs given in this study (calf).

    Measurements

    Cortisol elevation duration
    ≥ 12 h
    longer-acting ACTH

    Source sentences

    Summary
    With the longer-acting ACTH, plasma cortisol was elevated for at least 12 h following treatment and induced the expected physiological response of an elevation in blood glucose.
    1 context sentence
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In calves, longer-acting ACTHAR Gel increased blood glucose.

    In plain wordsIn calves, ACTHAR Gel increased blood glucose.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseBlood glucose
    Study

    calfn: not reported in source

    Calves
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intramuscularAs given in this study (calf).

    Source sentences

    Summary
    With the longer-acting ACTH, plasma cortisol was elevated for at least 12 h following treatment and induced the expected physiological response of an elevation in blood glucose.
    1 context sentence
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In rabbits, ACTHAR Gel increased plasma fibrinogen, first observed at 24 h and sustained for at least 96 h.

    In plain wordsIn rabbits, ACTHAR Gel increased blood fibrinogen from 24 h, with increases lasting at least 96 h.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreasePlasma fibrinogen
    Study

    rabbitn: not reported in source

    Rabbits
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.01
    both ACTH forms
    First observed elevation
    24 h
    after ACTH
    Sustained elevation
    ≥ 96 h
    both preparations

    Source sentences

    Summary
    In contrast, both forms of ACTH induced marked increases (p < 0.01) in plasma fibrinogen and fibronectin when administered to rabbits.
    3 context sentences
    Summary · context
    The elevation in the circulating levels of these proteins was first observed 24 h after ACTH administration, by which time plasma corticosteroid values had returned to pre-treatment values.
    Summary · context
    With both ACTH preparations the increases in the circulating levels of these proteins were sustained for at least 96 h.
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In rabbits, ACTHAR Gel increased plasma fibronectin, first observed at 24 h and sustained for at least 96 h.

    In plain wordsIn rabbits, ACTHAR Gel increased blood fibronectin from 24 h, with increases lasting at least 96 h.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreasePlasma fibronectin
    Study

    rabbitn: not reported in source

    Rabbits
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.01
    both ACTH forms
    First observed elevation
    24 h
    after ACTH
    Sustained elevation
    ≥ 96 h
    both preparations

    Source sentences

    Summary
    In contrast, both forms of ACTH induced marked increases (p < 0.01) in plasma fibrinogen and fibronectin when administered to rabbits.
    3 context sentences
    Summary · context
    The elevation in the circulating levels of these proteins was first observed 24 h after ACTH administration, by which time plasma corticosteroid values had returned to pre-treatment values.
    Summary · context
    With both ACTH preparations the increases in the circulating levels of these proteins were sustained for at least 96 h.
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),
  7. 07AnimalAnimal study (in vivo)Activity measurement

    In rabbits given ACTHAR Gel, plasma corticosteroids returned to pretreatment values by 24 h.

    In plain wordsIn rabbits given ACTHAR Gel, blood corticosteroids returned to pretreatment levels by 24 h.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changePlasma corticosteroids at 24 h
    Study

    rabbitn: not reported in source

    Rabbits
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Observation time
    24 h
    after ACTH

    Source sentences

    Summary
    The elevation in the circulating levels of these proteins was first observed 24 h after ACTH administration, by which time plasma corticosteroid values had returned to pre-treatment values.
    1 context sentence
    Summary · context
    The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel),

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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