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Study · In vitro (cell-free) · 1992

3 results

The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells.

Goldschmidt-Clermont PJ, Furman MI, Wachsstock D, Safer D, Nachmias VT, Pollard TD

Molecular biology of the cell1 Sept 1992Cited by 221 (Europe PMC)

PMID1330091 (opens in a new tab)PMCIDPMC275662 (opens in a new tab)DOI10.1091/mbc.3.9.1015 (opens in a new tab)PepBankPUB-01330091
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In vitro, thymosin beta‑4 bound actin monomers transiently with a stoichiometry of 1:1.

    In plain wordsIn lab tests, thymosin beta‑4 bound actin monomers briefly, one to one.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableBinding to actin monomers
    Study

    n: not reported in source

    Actin monomers with thymosin beta 4 and profilin
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both proteins bind actin monomers transiently with a stoichiometry of 1:1.
  2. 02LabIn vitro (cell-free)Activity measurement

    In vitro, thymosin beta‑4 bound to actin strongly inhibited the exchange of the nucleotide bound to actin by blocking its dissociation.

    In plain wordsIn lab tests, thymosin beta‑4 strongly slowed the swap of the nucleotide held by actin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseActin nucleotide exchange
    Study

    n: not reported in source

    Actin monomers with thymosin beta 4 and profilin
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When bound to actin, thymosin beta 4 strongly inhibits the exchange of the nucleotide bound to actin by blocking its dissociation

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism

    In vitro, low concentrations of profilin could overcome the inhibitory effects of high concentrations of thymosin beta‑4 on actin nucleotide exchange.

    In plain wordsIn lab tests, small amounts of profilin could overcome the slowing of nucleotide exchange by thymosin beta‑4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableReversal of thymosin beta 4 inhibition of nucleotide exchange by profilin
    Study

    n: not reported in source

    Actin monomers with thymosin beta 4 and profilin
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Because both proteins exchange rapidly between actin molecules, low concentrations of profilin can overcome the inhibitory effects of high concentrations of thymosin beta 4 on the nucleotide exchange.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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