Comparative haemodynamic effects of glucagon and isoprenaline in the early postoperative period in cardiac surgery.

Goenen M, Jaumin P, Raveau A, Tremouroux J

Scandinavian journal of thoracic and cardiovascular surgery1 Jan 1975

PMID1209206DOI10.3109/14017437509138641PepBankPUB-01209206

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, glucagon and isoprenaline had similar inotropic effects at the doses used.
In plain wordsAfter cardiac surgery, glucagon and isoprenaline had similar effects on heart contraction strength at the doses used.
Peptide
Glucagon
Outcome
Not applicableInotropic effect
Study
n = 16
Comparator
Isoprenaline
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
With the doses used, the inotropic effects of both drugs are similar, while the chronotropic action is statistically higher during isoprenaline infusion than after glucagon administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920601
02HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, glucagon had a statistically lower chronotropic effect than isoprenaline infusion.
In plain wordsAfter cardiac surgery, glucagon increased heart rate less than isoprenaline infusion.
Peptide
Glucagon
Outcome
DecreaseChronotropic effect
Study
n = 16
Comparator
Isoprenaline
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
With the doses used, the inotropic effects of both drugs are similar, while the chronotropic action is statistically higher during isoprenaline infusion than after glucagon administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920602
03HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, glucagon produced a smaller cardiac index increase than isoprenaline.
In plain wordsAfter cardiac surgery, glucagon increased cardiac index less than isoprenaline.
Peptide
Glucagon
Outcome
DecreaseCardiac index increase
Study
n = 16
Comparator
Isoprenaline
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
This fact explains the greater increase in cardiac index after isoprenaline administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920603
04HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, mean arterial pressure did not change significantly after glucagon.
In plain wordsAfter cardiac surgery, glucagon did not significantly change mean arterial pressure.
Peptide
Glucagon
Outcome
No significant changeMean arterial pressure
Study
n = 16
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mean arterial pressure shows no significant changes after either drug, while right atrial mean pressure decreases significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920604
05HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, right atrial mean pressure decreased significantly after glucagon.
In plain wordsAfter cardiac surgery, glucagon reduced mean pressure in the right atrium.
Peptide
Glucagon
Outcome
DecreaseRight atrial mean pressure
Study
n = 16
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mean arterial pressure shows no significant changes after either drug, while right atrial mean pressure decreases significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920605
06HumanNon-randomized trialEfficacy outcome
In postoperative cardiac surgery patients, peripheral vascular resistance remained mostly constant during the glucagon and isoprenaline study.
In plain wordsAfter cardiac surgery, peripheral vascular resistance remained mostly constant in the glucagon and isoprenaline study.
Peptide
Glucagon
Outcome
No significant changePeripheral vascular resistance
Study
n = 16
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Peripheral vascular resistance remained mostly constant.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920606
07HumanNon-randomized trialActivity measurement
In postoperative cardiac surgery patients, glucagon activity seemed maximal 10-15 minutes after injection and dissipated about 30 minutes later.
In plain wordsAfter cardiac surgery, glucagon activity seemed greatest 10-15 minutes after injection and disappeared about 30 minutes later.
Peptide
Glucagon
Outcome
Not applicableTime course of haemodynamic activity
Study
n = 16
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · single bolus injectionAs given in this study (human).
Measurements
Time to maximal activity
10 to 15 minutes
single bolus
Time after maximum to dissipation
≈ 30 minutes
single bolus
Source sentences
Summary
The activity of glucagon injected as a single bolus seems to be maximal 10 to 15 minutes after the injection and dissipates about 30 minutes later.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated.
Summary · context
Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs.
Report a problemFND-0120920607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.