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Study · Animal study (in vivo) · rat · 1975

5 results

Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon.

McGarry J, Wright PH, Foster DW

The Journal of clinical investigation1 Jun 1975Cited by 143 (Europe PMC)

PMID1133169 (opens in a new tab)PMCIDPMC301874 (opens in a new tab)DOI10.1172/jci108038 (opens in a new tab)PepBankPUB-01133169
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In fed rats, glucagon rapidly increased hepatic long-chain fatty acid oxidation capacity.

    In plain wordsIn fed rats, glucagon increased the liver's capacity to oxidize long-chain fatty acids.

    Peptide
    Glucagon
    Outcome
    IncreaseLong-chain fatty acid oxidation capacity
    Study

    ratn: not reported in source

    Fed rats with hepatic perfusion after dosing
    Outcome group
    Lipids · Liver
    Studied dose
    Dose not stated · 1 hAs given in this study (rat).

    Source sentences

    Summary
    The enhanced capacity for long-chain fatty acid oxidation and ketogenesis that develops in the rat liver between 6 and 9 h after the onset of starvation was shown to be inducible much more rapidly by administration of anti-insulin serum or glucagon to fed rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In fed rats, glucagon changed the liver from a nonketogenic to a ketogenic profile after one hour.

    In plain wordsIn fed rats, glucagon increased the liver's ketone production capacity after one hour.

    Peptide
    Glucagon
    Outcome
    IncreaseHepatic ketogenesis capacity
    Study

    ratn: not reported in source

    Fed rats with hepatic perfusion after dosing
    Outcome group
    Ketogenesis · Liver
    Studied dose
    Dose not stated · 1 hAs given in this study (rat).

    Measurements

    Treatment time
    1 h
    glucagon

    Source sentences

    Summary
    After only 1 h of treatment with either agent, the liver had clearly switched from a "nonketogenic" to a "ketogenic" profile, as determined by rates of acetoacetate and b-hydroxybutyrate production on perfusion with oleic acid.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In fed rats, glucagon depleted hepatic glycogen stores.

    In plain wordsIn fed rats, glucagon reduced liver glycogen stores.

    Peptide
    Glucagon
    Outcome
    DecreaseHepatic glycogen stores
    Study

    ratn: not reported in source

    Fed rats with hepatic perfusion after dosing
    Outcome group
    Glycemic control · Liver
    Studied dose
    Dose not stated · 1 hAs given in this study (rat).

    Source sentences

    Summary
    As was the case after starvation, the administration of insulin antibodies or glucagon resulted in depletion of hepatic glycogen stores and a proportional increase in the ability of the liver to oxidize long-chain fatty acids and (-)-octanoylcarnitine, suggesting that all three treatment schedules a…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In fed rats, glucagon increased hepatic capacity to oxidize (-)-octanoylcarnitine.

    In plain wordsIn fed rats, glucagon increased the liver's capacity to oxidize octanoylcarnitine.

    Peptide
    Glucagon
    Outcome
    IncreaseOctanoylcarnitine oxidation capacity
    Study

    ratn: not reported in source

    Fed rats with hepatic perfusion after dosing
    Outcome group
    Lipids · Liver
    Studied dose
    Dose not stated · 1 hAs given in this study (rat).

    Source sentences

    Summary
    As was the case after starvation, the administration of insulin antibodies or glucagon resulted in depletion of hepatic glycogen stores and a proportional increase in the ability of the liver to oxidize long-chain fatty acids and (-)-octanoylcarnitine, suggesting that all three treatment schedules a…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In fed rats, glucagon had little effect on plasma glucose, free fatty acids or ketone bodies, unlike anti-insulin serum.

    In plain wordsIn fed rats, glucagon had little effect on blood glucose, free fatty acids or ketones, unlike anti-insulin serum.

    Peptide
    Glucagon
    Outcome
    No significant changePlasma glucose, free fatty acid and ketone body concentrations
    Study

    ratn: not reported in source

    Fed rats with hepatic perfusion after dosing
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated · 1 hAs given in this study (rat).

    Source sentences

    Summary
    In contrast to anti-insulin serum, which produced marked elevations in plasma glucose, free fatty acid, and ketone body concentrations, glucagon treatment had little effect on any of these parameters, presumably due to enhanced insulin secretion after the initial stimulation of glycogenolysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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