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Study · Animal study (in vivo) · dog · 1979

3 results

Synergistic interactions of physiologic increments of glucagon, epinephrine, and cortisol in the dog: a model for stress-induced hyperglycemia.

Eigler N, Saccà L, Sherwin RS

The Journal of clinical investigation1 Jan 1979Cited by 166 (Europe PMC)

PMID762240 (opens in a new tab)PMCIDPMC371925 (opens in a new tab)DOI10.1172/jci109264 (opens in a new tab)PepBankPUB-00762240
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In normal conscious dogs, glucagon alone produced only mild or insignificant elevations in plasma glucose concentration.

    In plain wordsIn dogs, glucagon alone produced only small or insignificant increases in blood glucose.

    Peptide
    Glucagon
    Outcome
    IncreasePlasma glucose concentration
    Study

    dogn: not reported in source

    Normal conscious dogs
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · infusionAs given in this study (dog).

    Source sentences

    Summary
    Infusion of glucagon, epinephrine, or cortisol alone produced only mild or insignificant elevations in plasma glucose concentration.
    1 context sentence
    Summary · context
    To evaluate the role of anti-insulin hormone actions and interactions in the pathogenesis of stress-induced hyperglycemia, the counterregulatory hormones, glucagon, epinephrine, and cortisol were infused alone as well as in double and triple combinations into normal conscious dogs
  2. 02AnimalAnimal study (in vivo)Mechanism

    In normal conscious dogs, glucagon alone transiently increased glucose production.

    In plain wordsIn dogs, glucagon alone briefly increased glucose production.

    Peptide
    Glucagon
    Outcome
    IncreaseGlucose production
    Study

    dogn: not reported in source

    Normal conscious dogs
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · infusionAs given in this study (dog).

    Source sentences

    Summary
    Infusion of glucagon or epinephrine alone resulted in a transient rise in glucose production (as measured by [3-(3)H]glucose).
    1 context sentence
    Summary · context
    To evaluate the role of anti-insulin hormone actions and interactions in the pathogenesis of stress-induced hyperglycemia, the counterregulatory hormones, glucagon, epinephrine, and cortisol were infused alone as well as in double and triple combinations into normal conscious dogs
  3. 03AnimalAnimal study (in vivo)Mechanism

    In normal conscious dogs, glucagon infusion increased glucose clearance.

    In plain wordsIn dogs, glucagon infusion increased glucose removal from blood.

    Peptide
    Glucagon
    Outcome
    IncreaseGlucose clearance
    Study

    dogn: not reported in source

    Normal conscious dogs
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · infusionAs given in this study (dog).

    Source sentences

    Summary
    While glucagon infusion was accompanied by a rise in glucose clearance, with epinephrine there was a sustained, 20% fall in glucose clearance.
    1 context sentence
    Summary · context
    To evaluate the role of anti-insulin hormone actions and interactions in the pathogenesis of stress-induced hyperglycemia, the counterregulatory hormones, glucagon, epinephrine, and cortisol were infused alone as well as in double and triple combinations into normal conscious dogs

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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