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Study · Non-randomized trial · n = 4 · 1979

5 results

The effects of glucagon on protein metabolism in normal man.

Wolfe BM, Culebras JM, Aoki TT, O'Connor NE, Finley RJ, Kaczowka A, Moore FD

Surgery1 Aug 1979Cited by 41 (Europe PMC)

PMID380036 (opens in a new tab)PepBankPUB-00380036
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In healthy men, glucagon infusion raised plasma glucagon from 11 +/- 13 to 669 +/- 138 pg/ml during glucose infusion.

    In plain wordsIn healthy men, adding glucagon raised blood glucagon compared with glucose infusion alone.

    Peptide
    Glucagon
    Outcome
    IncreasePlasma glucagon concentration
    Study

    n = 4

    Comparator
    Glucose infusion alone
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg/day · intravenous infusion · 5 daysAs given in this study (human).

    Measurements

    Plasma glucagon
    11 pg/ml
    glucose infusion; +/- 13
    Plasma glucagon
    669 pg/ml
    glucagon infusion; +/- 138

    Source sentences

    Summary
    Glucagon concentration was suppressed during glucose infusion (11 +/- 13 pg/ml) and rose to levels seen in subjects with major trauma during glucagon infusion (669 +/- 138 pg/ml).
    3 context sentences
    Summary · context
    Four healthy men fasted for 6 days during intravenous infusion of glucose (750 gmday), establishing a steady state of minimal ureagenesis.
    Summary · context
    Glucagon (1 mg/day) then was added to the infusion for 5 days.
    Summary · context
    Glucose alone was given for the final 2 days.
  2. 02HumanNon-randomized trialMechanism

    In healthy men, glucagon increased urinary nitrogen excretion from 1.54 +/- 0.42 to 2.40 +/- 0.53 gm of N/sq m/day, through urea.

    In plain wordsIn healthy men, adding glucagon increased nitrogen loss in urine compared with glucose alone, through increased urea excretion.

    Peptide
    Glucagon
    Outcome
    IncreaseUrinary nitrogen excretion
    Study

    n = 4

    Comparator
    Glucose infusion alone
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    1 mg/day · intravenous infusion · 5 daysAs given in this study (human).

    Measurements

    Nitrogen excretion
    1.54 gm of N/sq m/day
    glucose infusion; +/- 0.42
    Nitrogen excretion
    2.4 gm of N/sq m/day
    glucagon infusion; +/- 0.53

    Source sentences

    Summary
    Nitrogen excretion increased to 2.40 +/- 0.53 gm of N/sq m/day with glucagon infusion, with urea accounting for the increased excretion.
    4 context sentences
    Summary · context
    Glucose infusion stabilized urine nitrogen excretion at 1.54 +/- 0.42 gm of N/sq m/day.
    Summary · context
    Four healthy men fasted for 6 days during intravenous infusion of glucose (750 gmday), establishing a steady state of minimal ureagenesis.
    Summary · context
    Glucagon (1 mg/day) then was added to the infusion for 5 days.
    Summary · context
    Glucose alone was given for the final 2 days.
  3. 03HumanNon-randomized trialMechanism

    In healthy men, glucagon infusion did not change 3-methylhistidine excretion.

    In plain wordsIn healthy men, adding glucagon did not change urine 3-methylhistidine compared with glucose infusion alone.

    Peptide
    Glucagon
    Outcome
    No significant change3-methylhistidine excretion
    Study

    n = 4

    Comparator
    Glucose infusion alone
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    1 mg/day · intravenous infusion · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Excretion of 3-methylhistidine was unchanged.
    3 context sentences
    Summary · context
    Four healthy men fasted for 6 days during intravenous infusion of glucose (750 gmday), establishing a steady state of minimal ureagenesis.
    Summary · context
    Glucagon (1 mg/day) then was added to the infusion for 5 days.
    Summary · context
    Glucose alone was given for the final 2 days.
  4. 04HumanNon-randomized trialMechanism

    In healthy men, plasma amino acid concentration fell markedly on the first day of glucagon infusion and then stabilized.

    In plain wordsIn healthy men, adding glucagon lowered blood amino acids compared with glucose infusion alone.

    Peptide
    Glucagon
    Outcome
    DecreasePlasma amino acid concentration
    Study

    n = 4

    Comparator
    Glucose infusion alone
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    1 mg/day · intravenous infusion · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Plasma amino acid concentration was strikingly reduced on the first day of glucagon infusion, where it stabilized.
    3 context sentences
    Summary · context
    Four healthy men fasted for 6 days during intravenous infusion of glucose (750 gmday), establishing a steady state of minimal ureagenesis.
    Summary · context
    Glucagon (1 mg/day) then was added to the infusion for 5 days.
    Summary · context
    Glucose alone was given for the final 2 days.
  5. 05HumanNon-randomized trialMechanism

    In healthy men, adding glucagon to glucose infusion changed forearm muscle nitrogen flux from net release to net uptake.

    In plain wordsIn healthy men, adding glucagon changed forearm muscle nitrogen movement from release to uptake compared with glucose alone.

    Peptide
    Glucagon
    Outcome
    IncreaseForearm skeletal muscle net nitrogen uptake
    Study

    n = 4

    Comparator
    Glucose infusion alone
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    1 mg/day · intravenous infusion · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Addition of glucagon to the glucose infusion resulted in a net uptake of nitrogen by forearm skeletal muscle.
    4 context sentences
    Summary · context
    Forearm flux showed a slight net release of amino acid nitrogen during glucose infusion.
    Summary · context
    Four healthy men fasted for 6 days during intravenous infusion of glucose (750 gmday), establishing a steady state of minimal ureagenesis.
    Summary · context
    Glucagon (1 mg/day) then was added to the infusion for 5 days.
    Summary · context
    Glucose alone was given for the final 2 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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