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Study · Non-randomized trial · n = 60 · 1976

6 results

Glucagon and barium enema examinations: a controlled clinical trial.

Harned RK, Stelling CB, Williams S, Wolf GL

AJR. American journal of roentgenology1 May 1976Cited by 10 (Europe PMC)

PMID178243 (opens in a new tab)DOI10.2214/ajr.126.5.981 (opens in a new tab)PepBankPUB-00178243
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    During barium enema examinations, patients and examiners reported significantly less discomfort with glucagon than placebo.

    In plain wordsDuring barium enema examinations, patients and examiners reported less discomfort with glucagon than placebo.

    Peptide
    Glucagon
    Outcome
    DecreaseExamination discomfort
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    When glucagon was given, both the patients and examiners noted significantly less discomfort and more bowel relaxation.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.
  2. 02HumanNon-randomized trialEfficacy outcome

    During barium enema examinations, patients and examiners reported significantly more bowel relaxation with glucagon than placebo.

    In plain wordsDuring barium enema examinations, glucagon produced more bowel relaxation than placebo.

    Peptide
    Glucagon
    Outcome
    IncreaseBowel relaxation
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    When glucagon was given, both the patients and examiners noted significantly less discomfort and more bowel relaxation.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.
  3. 03HumanNon-randomized trialSafety outcome

    In the barium enema study, glucagon produced no significant pulse changes.

    In plain wordsIn the barium enema study, glucagon did not significantly change pulse.

    Peptide
    Glucagon
    Outcome
    No significant changePulse
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Adverse events · Cardiovascular
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    There were no significant changes in pulse, blood pressure, or electrocardiogram.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.
  4. 04HumanNon-randomized trialSafety outcome

    In the barium enema study, glucagon produced no significant blood pressure changes.

    In plain wordsIn the barium enema study, glucagon did not significantly change blood pressure.

    Peptide
    Glucagon
    Outcome
    No significant changeBlood pressure
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    There were no significant changes in pulse, blood pressure, or electrocardiogram.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.
  5. 05HumanNon-randomized trialSafety outcome

    In the barium enema study, glucagon produced no significant electrocardiogram changes.

    In plain wordsIn the barium enema study, glucagon did not significantly change electrocardiograms.

    Peptide
    Glucagon
    Outcome
    No significant changeElectrocardiogram
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Adverse events · Cardiovascular
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    There were no significant changes in pulse, blood pressure, or electrocardiogram.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.
  6. 06HumanNon-randomized trialSafety outcome

    In the barium enema study, adverse reactions were too infrequent for a confident comparison between glucagon and placebo.

    In plain wordsAdverse reactions were too infrequent to compare glucagon with placebo confidently in the barium enema study.

    Peptide
    Glucagon
    Outcome
    Direction not reportedAdverse reactions
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Adverse events · Whole body
    Studied dose
    2 mgAs given in this study (human).

    Source sentences

    Summary
    Adverse reactions did not occur frequently enough to allow confident comparison of placebo and glucagon.
    2 context sentences
    Summary · context
    In a double-blind crossover clinical trial, 10 healthy volunteers received placebo and 2 mg glucagon intramuscularly preceding barium enema examination on separate days.
    Summary · context
    In addition, 50 patients were given either placebo or 2 mg glucagon prior to barium enema examination in a double-blind study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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