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Study · Animal study (in vivo) · rat · 1978

6 results

Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of rats.

Halestrap AP

The Biochemical journal1 Jun 1978Cited by 93 (Europe PMC)

PMID28727 (opens in a new tab)PMCIDPMC1185712 (opens in a new tab)DOI10.1042/bj1720389 (opens in a new tab)PepBankPUB-00028727
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon treatment increased liver mitochondrial pyruvate metabolism in sucrose or KCl media.

    In plain wordsIn rats, glucagon treatment increased pyruvate metabolism in isolated liver mitochondria compared with untreated rats.

    Peptide
    Glucagon
    Outcome
    IncreasePyruvate metabolism
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, no change in pyruvate carrier activity was apparent after glucagon treatment.

    In plain wordsIn rats, glucagon treatment showed no apparent change in pyruvate carrier activity compared with untreated rats.

    Peptide
    Glucagon
    Outcome
    Direction not reportedPyruvate carrier activity
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No change in the activity of the pyruvate carrier itself was apparent,
    1 context sentence
    Summary · context
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon treatment enhanced the maximum mitochondrial pyruvate transport rate under metabolizing conditions.

    In plain wordsIn rats, glucagon increased maximum pyruvate transport in liver mitochondria compared with untreated rats.

    Peptide
    Glucagon
    Outcome
    IncreaseMaximum pyruvate transport rate
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The maximum rate of transport under metabolizing conditions was enhanced by glucagon treatment.
    1 context sentence
    Summary · context
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, mitochondrial matrix pH rose after glucagon treatment.

    In plain wordsIn rats, glucagon treatment increased liver mitochondrial matrix pH compared with untreated rats.

    Peptide
    Glucagon
    Outcome
    IncreaseMitochondrial matrix pH
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    From the distribution of methylamine, ammonia and D-lactate and the Ki for inhibition by alpha-cyano-4-hydroxycinnamate it is concluded that the matrix is more acid than the medium and that the pH of the matrix rises after glucagon treatment.
    1 context sentence
    Summary · context
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.
  5. 05AnimalAnimal study (in vivo)Mechanism

    After glucagon treatment of rats, isolated liver mitochondria showed increased membrane potential, ATP concentration and oxygen uptake under metabolizing conditions.

    In plain wordsIn rats, glucagon treatment increased membrane potential, ATP concentration and oxygen uptake in isolated liver mitochondria.

    Peptide
    Glucagon
    Outcome
    IncreaseMembrane potential, ATP concentration and oxygen uptake
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The membrane potential, ATP concentration and O2 uptake were also increased under metabolizing conditions in glucagon-treated mitochondria.
    1 context sentence
    Summary · context
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon increased mitochondrial magnesium content from 38.8 +/- 1.2 to 47.5 +/- 2.0 ng-atoms/mg.

    In plain wordsIn rats, glucagon increased liver mitochondrial magnesium content compared with untreated rats.

    Peptide
    Glucagon
    Outcome
    IncreaseMitochondrial magnesium content
    Study

    ratn: not reported in source

    Liver mitochondria isolated after glucagon treatment
    Comparator
    Untreated rats
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Magnesium content
    38.8 ng-atoms/mg
    before; +/- 1.2; n = 26
    Magnesium content
    47.5 ng-atoms/mg
    glucagon; +/- 2.0; n = 26

    Source sentences

    Summary
    The mitochondrial Mg2+ content (mean +/- S.E.M.) was increased from 38.8 +/- 1.2 (n = 26) to 47.5 +/- 2.0 (n = 26) ng-atoms/mg by glucagon and the K+ content from 126.7 +/- 10.3 (n = 19) ng-atoms/mg.
    1 context sentence
    Summary · context
    Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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