In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
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| Peptide | Natural peptide Gonadorelin (GnRH, LHRH) | Natural peptide Oxytocin | |
|---|---|---|---|
| Identity | |||
| Kind | Natural peptide | Natural peptide | |
| Area | Sexual health and hormones | Sexual health and hormones | |
| Evidence | |||
| Amount of evidence | 115 | 3,492 (plus 1,148 on natural levels, listed separately) | |
| Evidence level | Has results from studies in people | Has results from studies in people | |
| Safety | |||
| Safety results | 9 (9 in people) | 157 (152 in people) | |
| Status | |||
| Approval | |||
| Sport (WADA) | |||
| Registered trials | 14 · 4 active4 more mention it but do not test it | 690 · 65 active238 more mention it but do not test it | |
Shared outcomes
From the regulatory data of each peptide.
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | Gonadorelin (GnRH, LHRH) | Oxytocin |
|---|---|---|
| Sex hormones and fertilityReproductive and sexual health | 8989 | 150328632 |
PepBank is a research reference. Talk to a doctor before you use any peptide.
No FDA approval and no central EU authorisation (EMA).
The FDA label for Pitocin says: “Antepartum: medically indicated induction of labor, stimulation or reinforcement of labor, adjunctive therapy in incomplete or inevitable abortion” No central EU authorisation (EMA).
| Adverse eventsWhole body |
|---|
99 |
1261233 |
| Receptor activity and mechanismNervous system and cognition | 77 | 28960801472 |
|---|
| Appetite and food intakeEndocrine and hormones | 22 | 946727 |
|---|
| PharmacokineticsPharmacology | 11 | 9168203 |
|---|
| Glycemic controlMetabolic and weight | 22 | 312254 |
|---|
| Body weightMetabolic and weight | 11 | 23176 |
|---|
| Bone and jointMusculoskeletal | 33 | 2020 |
|---|
| LipidsMetabolic and weight | 11 | 541 |
|---|
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
Top 3 of 14 trials, ranked by phase, then posted results and enrollment: 2 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)
Ferring Pharmaceuticals39 participants1 Apr 2014 to 23 Feb 2018
Primary Amenorrhea With Hypogonadotropic Hypogonadism
Ferring Pharmaceuticals132 participantsFeb 2005 to Nov 2005
InFertility
RenJi Hospital78 participantsest. 1 Jul 2019 to est. 30 Dec 2021
Polycystic Ovary Syndrome · Infertility · Ovulation Disorder
4 more mention it but do not test it. They only measure it or name it in their text.
Top 3 of 690 trials, ranked by phase, then posted results and enrollment: 3 completed · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)
University of Alabama at Birmingham1,798 participantsNov 2008 to Jun 2010
Uterine Atony · Postpartum Hemorrhage
Northwestern University1,003 participants28 Sept 2015 to 28 Sept 2020
Dystocia
University of Zimbabwe506 participants8 Apr 2018 to 30 Jun 2019
Post Partum Hemorrhage
238 more mention it but do not test it. They only measure it or name it in their text.
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
The other peptides have no randomized result on the same measure, so these results cannot be set side by side.
| Outcome | Gonadorelin (GnRH, LHRH) | Oxytocin |
|---|---|---|
| Appetite and food intakeMental health and moodCompared as: difference from placebo, in kcal | No comparable result 2 randomized-trial results measure it in another way or another unit. | −152 kcal Difference in caloric intake Dose studied: 24 IU four times daily8 weeksn = 612024 |
| Sex hormones and fertilityEndocrine and hormonesCompared as: value in the arm that got the peptide, in % | No comparable result 10 randomized-trial results measure it in another way or another unit. | 14.4% Mean percent change testosterone Dose studied: 24 IUn = 452020 |
| PharmacokineticsPharmacologyCompared as: value in the arm that got the peptide, in effect size | No randomized trial result 1 result from other study designs. | −1.12 effect size Effect size Dose studied: 48 IU/day6 weeksn = 1032020 |
| Body weightMetabolic and weightCompared as: difference from placebo, in g | No randomized trial result 1 result from other study designs. | 196 g Difference in total fat Dose studied: 24 IU four times daily8 weeksn = 612024 |
| Glycemic controlMetabolic and weightCompared as: value in the arm that got the peptide, in mmol/l × min | No randomized trial result 2 results from other study designs. | 2240 mmol/L × min Glucose AUC Placebo: 2190 mmol/L × min Dose studied: 24 IUn = 252024 |
| LipidsCardiovascularCompared as: difference from placebo, in mg/dl | No randomized trial result 1 result from other study designs. | −19.3 mg/dL LDL cholesterol change Dose studied: 24 IU 4 times per day8 weeksn = 212021 |
| Receptor activity and mechanismPharmacologyCompared as: value in the arm that got the peptide, in proteins | No randomized trial result 7 results from other study designs. | 198 proteins Differentially expressed proteins Dose studied: 24 IUsingle dosen = 192026 |
No comparable result
2 randomized-trial results measure it in another way or another unit.
−152 kcal
Difference in caloric intake
Dose studied: 24 IU four times daily8 weeksn = 612024
No comparable result
10 randomized-trial results measure it in another way or another unit.
14.4%
Mean percent change testosterone
Dose studied: 24 IUn = 452020
No randomized trial result
1 result from other study designs.
−1.12 effect size
Effect size
Dose studied: 48 IU/day6 weeksn = 1032020
No randomized trial result
1 result from other study designs.
196 g
Difference in total fat
Dose studied: 24 IU four times daily8 weeksn = 612024
No randomized trial result
2 results from other study designs.
2240 mmol/L × min
Glucose AUC
Placebo: 2190 mmol/L × min
Dose studied: 24 IUn = 252024
No randomized trial result
1 result from other study designs.
−19.3 mg/dL
LDL cholesterol change
Dose studied: 24 IU 4 times per day8 weeksn = 212021
No randomized trial result
7 results from other study designs.
198 proteins
Differentially expressed proteins
Dose studied: 24 IUsingle dosen = 192026