CompletedPhase 3NCT01381484
Argireline in Treatment of Periorbital Wrinkles
Mahidol University70 participantsMar 2009 to Sept 2009
Wrinkles
Compare peptides
Compare two to four peptides side by side. Counts are exact.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
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| Peptide | Synthetic analog Argireline (acetyl hexapeptide-8) | Natural peptide L-carnosine | |
|---|---|---|---|
| Identity | |||
| Kind | Synthetic analog | Natural peptide | |
| Area | Skin and hair | Skin and hair | |
| Evidence | |||
| Amount of evidence | 77 | 1,203 | |
| Evidence level | Has results from studies in people | Has results from studies in people | |
| Safety | |||
| Safety results | 11 (6 in people) | 34 (20 in people) | |
| Status | |||
| Approval | Not recorded | ||
| Sport (WADA) | |||
| Registered trials | 34 more mention it but do not test it | 2 | |
Shared outcomes
From the regulatory data of each peptide.
The FDA, the EMA and the other sources we use show no approval (as of 22 Oct 2026).
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | Argireline (acetyl hexapeptide-8) | L-carnosine |
|---|---|---|
| Receptor activity and mechanismSkin and wound | 55 | 16510362 |
| Inflammation markersImmune and inflammation |
PepBank is a research reference. Talk to a doctor before you use any peptide.
11 |
9714794 |
| PharmacokineticsPharmacology | 99 | 4820262 |
|---|
| Skin and hairSkin and wound | 4321202 | 33 |
|---|
| Adverse eventsWhole body | 10523 | 251681 |
|---|
| Mitochondrial functionWhole body | 11 | 462224 |
|---|
| Aging markersWhole body | 33 | 1477 |
|---|
| Immune responseImmune and inflammation | 11 | 88 |
|---|
| Infection and antimicrobial activityInfection | 11 | 11 |
|---|
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
The other peptides have no randomized result on the same measure, so these results cannot be set side by side.
| Outcome | Argireline (acetyl hexapeptide-8) | L-carnosine |
|---|---|---|
| Skin and hairSkin and woundCompared as: value in the arm that got the peptide, in % | 48.9% Anti-wrinkle efficacy Placebo: 0% 4 weeksn = 602013 | No randomized trial result 3 results from other study designs. |
| Adverse eventsEyeCompared as: value in the arm that got the peptide, in % | No comparable result 1 randomized-trial result measure it in another way or another unit. | 30% Adverse events Placebo: 14% Dose studied: 2 g/day3 monthsn = 752012 |
48.9%
Anti-wrinkle efficacy
Placebo: 0%
4 weeksn = 602013
No randomized trial result
3 results from other study designs.
No comparable result
1 randomized-trial result measure it in another way or another unit.
30%
Adverse events
Placebo: 14%
Dose studied: 2 g/day3 monthsn = 752012
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
3 trials · 2 completed · 1 stopped early · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)
Mahidol University70 participantsMar 2009 to Sept 2009
Wrinkles
National Institute of Neurological Disorders and Stroke (NINDS)8 participantsNov 2012 to May 2015
Focal Dystonia
University of California, Davis14 participantsJan 2016 to Feb 2016
Oily Skin
4 more mention it but do not test it. They only measure it or name it in their text.
2 trials · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)
Monash University40 participantsOct 2016 to est. Jul 2023
Poor Glycemic Control · Cardiovascular Risk Factors · Cognitive Function 1, Social
University of Louisville299 participants1 Apr 2018 to 1 Nov 2022
Air Pollution Toxicity