CompletedPhase 3NCT01381484
Argireline in Treatment of Periorbital Wrinkles
Mahidol University70 participantsMar 2009 to Sept 2009
Wrinkles
Compare peptides
Compare two to four peptides side by side. Counts are exact.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
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| Peptide | Synthetic analog Argireline (acetyl hexapeptide-8) | Synthetic analog Difelikefalin | |
|---|---|---|---|
| Identity | |||
| Kind | Synthetic analog | Synthetic analog | |
| Area | Skin and hair | Skin and hair | |
| Evidence | |||
| Amount of evidence | 77 | 272 | |
| Evidence level | Has results from studies in people | Has results from studies in people | |
| Safety | |||
| Safety results | 11 (6 in people) | 123 (123 in people) | |
| Status | |||
| Approval | |||
| Sport (WADA) | |||
| Registered trials | 34 more mention it but do not test it | 28 · 2 active | |
Shared outcomes
From the regulatory data of each peptide.
The FDA, the EMA and the other sources we use show no approval (as of 22 Oct 2026).
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | Argireline (acetyl hexapeptide-8) | Difelikefalin |
|---|---|---|
| Adverse eventsWhole body | 10523 | 103103 |
| Skin and hair |
PepBank is a research reference. Talk to a doctor before you use any peptide.
The FDA label for Korsuva says: “Moderate to severe CKD-associated pruritus in adults receiving hemodialysis”
4321202 |
595621 |
| PharmacokineticsPharmacology | 99 | 24231 |
|---|
| Inflammation markersImmune and inflammation | 11 | 8431 |
|---|
| Receptor activity and mechanismSkin and wound | 55 | 4211 |
|---|
| Immune responseImmune and inflammation | 11 | 11 |
|---|
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
The other peptides have no randomized result on the same measure, so these results cannot be set side by side.
| Outcome | Argireline (acetyl hexapeptide-8) | Difelikefalin |
|---|---|---|
| Skin and hairSkin and woundCompared as: difference from placebo, in nrs points | No comparable result 16 randomized-trial results measure it in another way or another unit. | −0.97 NRS points Between-group difference in NRS change at week 4 Dose studied: 0.5 μg/kg three times per week6 weeksn = 1782023 |
| Adverse eventsEyeCompared as: value in the arm that got the peptide, in % | No comparable result 1 randomized-trial result measure it in another way or another unit. | 78% Treatment-emergent adverse events Placebo: 42% Dose studied: 0.5, 1.0, or 1.5 μg/kg thrice weekly8 weeksn not reported2020 |
No comparable result
16 randomized-trial results measure it in another way or another unit.
−0.97 NRS points
Between-group difference in NRS change at week 4
Dose studied: 0.5 μg/kg three times per week6 weeksn = 1782023
No comparable result
1 randomized-trial result measure it in another way or another unit.
78%
Treatment-emergent adverse events
Placebo: 42%
Dose studied: 0.5, 1.0, or 1.5 μg/kg thrice weekly8 weeksn not reported2020
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
3 trials · 2 completed · 1 stopped early · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)
Mahidol University70 participantsMar 2009 to Sept 2009
Wrinkles
National Institute of Neurological Disorders and Stroke (NINDS)8 participantsNov 2012 to May 2015
Focal Dystonia
University of California, Davis14 participantsJan 2016 to Feb 2016
Oily Skin
4 more mention it but do not test it. They only measure it or name it in their text.
Top 3 of 28 trials, ranked by phase, then posted results and enrollment: 3 completed · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)
Cara Therapeutics, Inc.473 participants17 Jul 2018 to 30 Mar 2020
Uremic Pruritus
Cara Therapeutics, Inc.378 participants20 Feb 2018 to 26 Mar 2020
Uremic Pruritus
Cara Therapeutics, Inc.288 participants14 Aug 2017 to 11 Feb 2020
Uremic Pruritus