In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
Swipe sideways to see every peptide.
| Peptide | Conjugate Adipotide | Synthetic analog Semaglutide | |
|---|---|---|---|
| Identity | |||
| Kind | Conjugate | Synthetic analog | |
| Area | Weight and metabolic | Weight and metabolic | |
| Evidence | |||
| Amount of evidence | 5 | 4,624 | |
| Evidence level | Results from animal studies onlyRegistered trials, no results from human studies | Has results from studies in people | |
| Safety | |||
| Safety results | 1 (0 in people) | 1,224 (1,221 in people) | |
| Status | |||
| Approval | |||
| Sport (WADA) | |||
| Registered trials | 1 | 663 · 284 active124 more mention it but do not test it | |
Shared outcomes
From the regulatory data of each peptide.
Its most advanced trial is in phase 1. The FDA, the EMA and the other sources we use show no approval (as of 13 Oct 2026).
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | Adipotide | Semaglutide |
|---|---|---|
| Body weightMetabolic and weight | 11 | 969954105 |
| Glycemic control |
PepBank is a research reference. Talk to a doctor before you use any peptide.
The FDA label for Ozempic says: “Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes; reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease; reduce the risk of sustained eGFR decline…”
11 |
66866512 |
| Kidney functionKidney and urinary | 11 | 1361351 |
|---|
| Body compositionMetabolic and weight | 11 | 3939 |
|---|
| Receptor activity and mechanismMetabolic and weight | 11 | 91611 |
|---|
Each analog against its native parent, residue by residue. Substitutions, non-standard residues and modifications are marked. Calculated from the two sequences.
Semaglutide differs from Glucagon-like peptide 1 (7-37) at 2 positions and carries 1 added group.
What is different
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)
M.D. Anderson Cancer Center4 participants24 May 2012 to 2 Jan 2019
Prostate Cancer
Top 3 of 663 trials, ranked by phase, then posted results and enrollment: 3 completed · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)
Novo Nordisk A/S17,604 participants24 Oct 2018 to 29 Jun 2023
Overweight · Obesity
Novo Nordisk A/S9,651 participants17 Jun 2019 to 23 Aug 2024
Diabetes Mellitus, Type 2
Novo Nordisk A/S3,533 participants17 Jun 2019 to 9 Jan 2024
Diabetes Mellitus, Type 2
124 more mention it but do not test it. They only measure it or name it in their text.
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
The other peptides have no randomized result on the same measure, so these results cannot be set side by side.
| Outcome | Adipotide | Semaglutide |
|---|---|---|
| Body weightMetabolic and weightCompared as: difference from placebo, in % | No randomized trial result 1 result from other study designs. | −2.54% Body weight change at 13 weeks Dose studied: maximum 14 mg once dailyn = 9,6502026 |
| Glycemic controlMetabolic and weightCompared as: difference from placebo, in percentage points | No randomized trial result 1 result from other study designs. | −0.87 percentage points HbA1c change at 13 weeks Dose studied: maximum 14 mg once dailyn = 9,6502026 |
| Body compositionMetabolic and weightCompared as: difference from placebo, in kg | No randomized trial result 1 result from other study designs. | −2.5 kg Lean body mass change Dose studied: 2.4 mg/wk24 weeksn = 1012026 |
| Kidney functionKidney and urinaryCompared as: difference from placebo, in % | No randomized trial result 1 result from other study designs. | −52.1% UACR change Dose studied: 2.4 mg per week24 weeksn = 1012025 |
No randomized trial result
1 result from other study designs.
−2.54%
Body weight change at 13 weeks
Dose studied: maximum 14 mg once dailyn = 9,6502026
No randomized trial result
1 result from other study designs.
−0.87 percentage points
HbA1c change at 13 weeks
Dose studied: maximum 14 mg once dailyn = 9,6502026
No randomized trial result
1 result from other study designs.
−2.5 kg
Lean body mass change
Dose studied: 2.4 mg/wk24 weeksn = 1012026
No randomized trial result
1 result from other study designs.
−52.1%
UACR change
Dose studied: 2.4 mg per week24 weeksn = 1012025