hCG is a hormone in approved medicines such as Pregnyl, and enclomiphene is a clomiphene form studied for low testosterone in men, not approved by the FDA. Both are banned in sport, and studies of both in people measured sex hormones. This page compares their results.
Comparing 2 records · Data version 308560
Swipe sideways to see every peptide.
| Peptide | Natural peptide hCG (human chorionic gonadotropin) | |
|---|---|---|
| Identity | ||
| Kind | Natural peptide | Small molecule |
| Area | Sexual health and hormones | Sexual health and hormones |
| Evidence | ||
| Amount of evidence | 95 | 153 |
| Evidence level | Has results from studies in people | Has results from studies in people |
| Safety | ||
| Safety results | 4 (4 in people) | 18 (5 in people) |
| Status | ||
| Approval | ||
| Sport (WADA) | ||
| Registered trials | 123 · 9 active166 more mention it but do not test it | 25 |
Shared outcomes
From the regulatory data of each peptide.
The FDA label for Pregnyl says: “Selected male hypogonadotropic hypogonadism, prepubertal cryptorchidism without anatomical obstruction and selected female ovulation induction”
Its most advanced trial is in phase 3. The FDA, the EMA and the other sources we use show no approval (as of 21 Oct 2026).
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | hCG (human chorionic gonadotropin) | Enclomiphene |
|---|---|---|
| Sex hormones and fertilityReproductive and sexual health | 9292 | 89324017 |
| Adverse eventsReproductive and sexual health | 33 | 55 |
PepBank is a research reference. Talk to a doctor before you use any peptide.
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
The other peptides have no randomized result on the same measure, so these results cannot be set side by side.
| Outcome | hCG (human chorionic gonadotropin) | Enclomiphene |
|---|---|---|
| Sex hormones and fertilityReproductive and sexual healthCompared as: value in the arm that got the peptide, in men (of 7) | No comparable result 9 randomized-trial results measure it in another way or another unit. | 7 men (of 7) Men with elevated sperm count · enclomiphene citrate, 3 months 3 monthsn = 72013 |
No comparable result
9 randomized-trial results measure it in another way or another unit.
7 men (of 7)
Men with elevated sperm count · enclomiphene citrate, 3 months
3 monthsn = 72013
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
Top 3 of 123 trials, ranked by phase, then posted results and enrollment: 3 completed · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)
Organon and Co1,509 participants27 Jun 2006 to 15 Jan 2008
In Vitro Fertilization
Merck KGaA, Darmstadt, Germany939 participants31 Jan 2014 to 31 Aug 2015
Infertility
Regionshospitalet Viborg, Skive384 participantsJan 2009 to Dec 2011
OHSS (Ovarian Hyperstimulation)
166 more mention it but do not test it. They only measure it or name it in their text.
Top 3 of 25 trials, ranked by phase, then posted results and enrollment: 3 completed · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)
Repros Therapeutics Inc.499 participantsMay 2012 to Oct 2013
Secondary Hypogonadism
Repros Therapeutics Inc.181 participantsNov 2012 to Sept 2013
Secondary Hypogonadism
Repros Therapeutics Inc.151 participantsAug 2012 to Mar 2013
Secondary Hypogonadism
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated