Trial · Interventional
RecruitingPhase 1Registry dataA Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Overweight or Obesity, Compared to a Low-calorie Diet or Placebo
Overview
- Status
- Recruiting
- Phase
- Phase 1
- Enrollment
- 120 participants (estimated)
- Sponsor
- Novo Nordisk A/S · Industry
- Design
- Randomized · Quadruple masking
- Countries
2 countries
Denmark, Netherlands
- Start
- 3 Aug 2026
- Primary completion
- 18 Sept 2028 (estimated)
- Completion
- 18 Sept 2028 (estimated)
- First posted
- 11 Aug 2026
- Last update posted
- 1 Oct 2026
- Conditions
- Overweight · Obesity
Timeline
1 trial · 1 ongoing
- Completed
- Ongoing
- Not yet recruiting
- Stopped
- Estimated dates (est.)
- Results posted
- Ph 1
A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Overweight or Obesity, Compared to a Low-calorie Diet or Placebo
NCT077570873 Aug 2026 to est. 18 Sept 2028
Registry summary
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
The purpose of this clinical study is to evaluate how NNC0487-0111 affects the amount of energy the body uses in people living with obesity or overweight following weight loss. This will be compared with the amount of energy used by participants who achieve weight loss through a low-calorie diet and by participants receiving placebo (without weight loss).
Interventions
- NNC0487-0111Drug
- PlaceboDrug
- LEDBehavioral
Arms3
Experimental
NNC0487-0111
Participants will receive once weekly subcutaneous injection of NNC0487-0111.
Placebo comparator
Placebo
Participants will receive once weekly subcutaneous injection of placebo matched to NNC0487-0111.
Other
Low Energy Diet (LED)
Participants will receive a low-energy dietary designed to achieve a reduction in body weight.
Primary outcomes1
Outcomes the sponsor listed as primary.
Change in sleeping metabolic rate (SMR)
Time frame · Baseline (week 0) to week 12-26
Registry description
Measured in kilojoules per day (kJ/day)
Secondary outcomes(4)
Change in 24-hour energy expenditure (EE)
Time frame · Baseline (week 0) to week 12-26
Registry description
Measured in kJ/day.
Change in basal metabolic rate (BMR)
Time frame · Baseline (week 0) to week 12-26
Registry description
Measured in kJ/day.
Change in resting metabolic rate (RMR)
Time frame · Baseline (week 0) to week 12-26
Registry description
Measured in kJ/day.
Change in diet-induced thermogenesis (DIT)
Time frame · Baseline (week 0) to week 12-26
Registry description
Measured in kJ/day.
Posted results
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
A trial that is still running, or that stopped early, may post results later.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies0
Studies that cite this trial.
No study cites this trial.
Eligibility
Who could join, as posted.
- Sex
- All
- Age
- from 18 Years
- Healthy volunteers
- Not accepted
Inclusion and exclusion criteria, as posted
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