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Trial · Interventional

CompletedPhase 1Registry data

A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906

NCTNCT05296733 (opens ClinicalTrials.gov in a new tab)Other id1404-0010Other id2021-006247-10

Overview

Status
Completed
Phase
Phase 1
Enrollment
82 participants (actual)
Sponsor
Boehringer Ingelheim · Industry
Design
Not randomized · Open label (no masking)
Countries
6 countries

United States, Germany, Hungary, New Zealand, Poland, Slovakia

Start
27 Apr 2022
Primary completion
29 Dec 2023
Completion
29 Dec 2023
First posted
25 Mar 2022
Last update posted
15 Aug 2024
Conditions
Healthy · Liver Diseases · Obesity

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
202220232024
  1. Ph 1

    A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906

    NCT05296733

    27 Apr 2022 to 29 Dec 2023

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

This study is open to adults who have different levels of liver problems and adults who are healthy. People with or without overweight or obesity can take part. This study has 2 parts. The purpose of Part 1 is to find out whether having liver problems influences how BI 456906 is taken up in the body. The purpose of Part 2 is to find out whether having liver problems influences how people with overweight and obesity tolerate different doses of BI 456906. In Part 1, participants get a single injection of BI 456906 under their skin and stay at the study site for 2 nights afterwards. They are in the study for about a month. During this time, they visit the study site about 8 more times. The doctors compare the amount of BI 456906 in the blood of healthy people and people with liver problems. In Part 2, participants get 1 or 2 injections of BI 456906 once a week under their skin for 28 weeks. At the beginning, they get lower doses of BI 456906. Over time, they get higher doses until they reach a certain dose of BI 456906. This dose is then maintained until the end of the treatment. Participants in Part 2 are in the study for about 7 months. During this time, they visit the study site about 16 times and get about 15 phone calls from the site staff. The doctors record the number of people with health problems that could have been caused by treatment with BI 456906. They compare the results between participants with liver problems and those without liver problems. In both parts, doctors also regularly check participants' health and take note of any unwanted effects.

Interventions

  • BI 456906Drug

Arms7

  • Experimental

    Part A: BI 456906: Cohort 1

    Healthy subjects

  • Experimental

    Part A: BI 456906: Cohort 2

    Patients with cirrhosis + Child-Turcotte-Pugh (CTP) Class A

  • Experimental

    Part A: BI 456906: Cohort 3

    Patients with cirrhosis + CTP Class B

  • Experimental

    Part A: BI 456906: Cohort 4

    Patients with cirrhosis + CTP Class C

  • Experimental

    Part B: BI456906: Cohort 1

    Patients with overweight/obesity without cirrhosis/hepatic impairment

  • Experimental

    Part B: BI456906: Cohort 2

    Patients with overweight/obesity with cirrhosis + CTP Class A

  • Experimental

    Part B: BI456906: Cohort 3

    Patients with overweight/obesity with cirrhosis + CTP Class B

Primary outcomes3

Outcomes the sponsor listed as primary.

  1. Part A: Area under the concentration-time curve of BI 456906 in plasma over the time interval from 0 extrapolated to infinity (AUC0-∞)

    Time frame · Up to 360 hours

  2. Part A: Maximum measured concentration of BI 456906 in plasma (Cmax)

    Time frame · Up to 360 hours

  3. Part B: Percentage of patients treated who experience treatment-emergent adverse event

    Time frame · Up to Day 218

Secondary outcomes(1)
  1. Part A: Percentage of patients treated who experience treatment-emergent adverse event

    Time frame · Up to Day 35

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies1

Studies that cite this trial.

Studies with results

1 study on this page

Indexing hint: Clinical trial · 2024

9 results

Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis.

Lawitz et al. 2024Journal of hepatologycited by 51

PMID 38857788DOI 10.1016/j.jhep.2024.06.003PUB-38857788

CC BY9 results

Eligibility

Who could join, as posted.

Sex
All
Age
from 18 Years up to 75 Years
Healthy volunteers
Not accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria -Part A: * Male or female subjects with age ≥18 years (or the minimum country specific age of consent if \>18 years) and 75 years, inclusive at the screening visit. * Body mass index (BMI) of 18.5-40.0 kg/m2 (inclusive). * Signed and dated written informed consent in accordance with International Council on Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial. * Women of childbearing potential must be willing and able to use two forms of effective contraception where at least one form is highly effective method of birth control per ICH M3 (R2) that results in a low failure rate (i.e. \<1% per year when used consistently and correctly). A list of contraception methods meeting these criteria is provided in the subject information. Please note that oral contraceptives are not allowed during the treatment period. A woman is considered of childbearing potential, i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. Tubal ligation is NOT a method of permanent sterilisation. A postmenopausal state is defined as no menses for 12 months without an alternative medical cause. Further inclusion criteria apply. -Part B: * Male or female subjects between the ages of ≥18 (or the minimum country specific age of consent if \>18 years) and 75 years, inclusive, at the screening visit. * Subjects with overweight or obesity, defined as BMI ≥27 kg/m2 at the screening visit. * A minimum absolute body weight of 70 kg for females and 80 kg for males at the screening visit. * Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial. Further inclusion criteria apply. Exclusion criteria -Part A: * Estimated Glomerular Filtration Rate (eGFR) \<60 mL/min/1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] formula). * Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, manifest hypo- or hyperthyroidism at screening. * Calcitonin ≥20 pg/mL (5.84 pmol/L) at the screening visit. * History of chronic or acute pancreatitis or elevation of serum lipase/amylase \>2×ULN, or fasting serum triglyceride levels of \>500 mg/dL (\>5.65 mmol/L) at screening. Further exclusion criteria apply. -Part B: * Prior surgery of the gastrointestinal tract that could interfere with body weight (including minimally invasive/endoscopic bariatric devices, bariatric surgery including metabolic operation that involves resection and/or reconstruction of any portion of the gastrointestinal tract) except appendectomy and simple hernia repair before randomization. However, a subject previously treated with reversible weight loss devices such as gastric banding, or intragastric balloon and removed longer than 12 months before screening should not be excluded. * Glycosylated Hemoglobin, Type A1 (HbA1c) ≥11% at screening or diagnosed with type 1 diabetes mellitus. * Exposure to Glucagon-like-peptide 1 (GLP-1) receptor agonist-based therapies (within 3 months prior to screening or within 5 half-lives of the drug, whichever is longer). * Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, manifest hypo- or hyperthyroidism at screening. Further exclusion criteria apply.

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