Trial · Interventional
CompletedNot applicableRegistry dataBelgium
1 trial · 1 completed
Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli
NCT0444364715 Dec 2018 to 30 Jan 2020
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
In this study, a randomized, placebo-controlled between-subject design is adopted to investigate the effect of a single-dose of intranasally administered OT on approach-avoidance related motivational tendencies during the processing of a series of social and non-social, positively and negatively valenced stimuli. To obtain a behavioral measure of approach-avoidance tendencies, participants will be able to control the viewing time of the presented stimuli, by pressing 'up' or 'down' on a keyboard. During stimulus presentation neurophysiological recordings will be performed to obtain a neural measure of approach-avoidance motivational tendencies, based on electroencephalographic recordings (EEG: frontal alpha asymmetry). Also assessments of autonomic arousal, based on skin conductance recordings will be collected.
Experimental
Oxytocin
Syntocinon nasal spray (40 IU/ml; oxytocin, product code RVG 03716); single intranasal dose of 24 international units (IU; 3 puffs of 4 IU per nostril)
Placebo comparator
Placebo
Saline natriumchloride solution nasal spray; single intranasal dose (3 puffs per nostril)
Outcomes the sponsor listed as primary.
Change in EEG frontal alpha asymmetry after nasal spray administration
Time frame · Average over trials, baseline and approximately 30 minutes after nasal spray administration
The influence of oxytocin administration on EEG frontal alpha asymmetry
Change in behavioral approach-avoidance (number of up or down key presses, prolonging or shortening the viewing time towards presented stimuli)
Time frame · Average over trials, baseline and approximately 30 minutes after nasal spray administration
During the presentation of a series of stimuli, participants will be able to prolong or shorten the viewing time towards the presented stimuli, by pressing an 'up' or 'down' key on a keyboard. The number of up versus down key-presses will be taken as a measure of behavioral approach-avoidance. The influence of oxytocin administration on the number of up or down key presses will be assessed.
Change in skin conductance (type of electrodermal recording) after nasal spray administration
Time frame · Average over trials, baseline and approximately 30 minutes after nasal spray administration
The influence of oxytocin adminstration on skin conductance
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
Completed trials do not always post results.
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Studies that cite this trial.
1 study on this page
Indexing hint: Randomized controlled trial · 2021
Alaerts et al. 2021Scientific reportscited by 17
PMID 34880300PMC8655079DOI 10.1038/s41598-021-02914-8PUB-34880300
1 study on this page
Indexing hint: Review · 2014
Harari-Dahan et al. 2014Neuroscience and biobehavioral reviewscited by 109
PMID 25454355DOI 10.1016/j.neubiorev.2014.10.007PUB-25454355
Who could join, as posted.
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