Trial · Interventional

CompletedNot applicableResults postedRegistry data

Oxytocin Pathways and the Health Effects of Human-Animal Interaction

NCTNCT03852264Other id1808883345

Open at ClinicalTrials.govAsk about this trial

This trial does not test a peptide that PepBank tracks.

Measures Oxytocin, does not give it. It appears in an outcome measure.

Overview

Status: Completed
Phase: Not applicable
Enrollment: 55 participants (actual)
Sponsor: University of Arizona · Other
Design: Not randomized · Single masking
Countries: 1 country
United States
Start: 8 Mar 2019
Primary completion: 10 Jan 2022
Completion: 10 Jan 2022
First posted: 25 Feb 2019
Last update posted: 12 Nov 2024
Conditions: Human-Animal Bond · Human-Animal Interaction

Timeline

1 trial · 1 completed · 1 with posted results

Completed
Ongoing
Not yet recruiting
Stopped
Estimated dates (est.)
Results posted

20192020202120222023

N/A
Oxytocin Pathways and the Health Effects of Human-Animal Interaction
NCT03852264
8 Mar 2019 to 10 Jan 2022

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

This study investigates the roles of oxytocin pathways in human-animal interaction.

Interventions

Pet dogBehavioral
Unfamiliar dogBehavioral
Nonsocial controlBehavioral

Arms2

Experimental
Pet Dog Interaction first, then Nonsocial Control, then Unfamiliar Dog Interaction
Participant's first study visit involved 25 minutes of interaction with the participant's pet dog. The second study visit involved 25 minutes of individual play with toys. The third study visit involved 25 minutes of interaction with an unfamiliar dog.
Experimental
Unfamiliar Dog Interaction first, then Nonsocial Control, then Pet Dog Interaction
Participant's first study visit involved 25 minutes of interaction with an unfamiliar dog. The second study visit involved 25 minutes of individual play with toys. The third study visit involved 25 minutes of interaction with the participant's pet dog.

Primary outcomes2

Outcomes the sponsor listed as primary.

Salivary Oxytocin, Area Under the Curve
Time frame · baseline, 15 minutes
Registry description
Change from baseline measured as the area under the curve with respect to the initial value (AUCi).
Urinary Oxytocin, Area Under the Curve
Time frame · baseline, 50 minutes
Registry description
Change from baseline measured as the area under the curve with respect to the initial value (AUCi).

Secondary outcomes(2)

Salivary Cortisol, Area Under the Curve
Time frame · baseline, 50 minutes
Registry description
Change from baseline measured as the area under the curve with respect to the initial value (AUCi).
Urinary Vasopressin, Area Under the Curve
Time frame · baseline, 50 minutes
Registry description
Change from baseline measured as the area under the curve with respect to the initial value (AUCi).

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

Primary outcome results

Primary outcomeMean· baseline, 15 minutes

Salivary Oxytocin, Area Under the Curve

Group	Value (pg/mL x minutes)	Spread
Pet Dog Interaction	-3.03	1.59
Unfamiliar Dog Interaction	-3.83	1.67
Toys Interaction	-5.57	1.73

Primary outcomeMean· baseline, 50 minutes

Urinary Oxytocin, Area Under the Curve

Group	Value (pg/ml x minutes)	Spread
Pet Dog Interaction	0.261	0.372
Unfamiliar Dog Interaction	-0.219	0.366
Toys Interaction	-0.180	0.407

Secondary and other outcome results(2)

Secondary outcomeMean· baseline, 50 minutes

Salivary Cortisol, Area Under the Curve

Group	Value (pg/mL x minutes)	Spread
Pet Dog Interaction	-99.7	20.2
Unfamiliar Dog Interaction	-221.1	70.1
Toys Interaction	-103.0	29.2

Secondary outcome· baseline, 50 minutes

Urinary Vasopressin, Area Under the Curve

Group	Value
Pet Dog Interaction	not posted
Unfamiliar Dog Interaction	not posted
Toys Interaction	not posted

Adverse events, as posted

Adverse events as posted: participants affected out of participants at risk, by group
Group	Deaths	Serious events	Other events
Pet Dog InteractionParticipants interacted with their pet dog for 25 minutes	0 / 55	0 / 55	0 / 55
Unfamiliar Dog InteractionParticipants interacted with an unfamiliar dog for 25 minutes	0 / 54	0 / 54	0 / 54
Toys InteractionParticipants interacted with an assortment of toys for 25 minutes	0 / 55	0 / 55	0 / 55

Each cell reads participants affected / participants at risk, as the registry posted them.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies0

Studies that cite this trial.

No study cites this trial.

Eligibility

Who could join, as posted.

Sex: All
Age: from 8 Years up to 10 Years
Healthy volunteers: Accepted

Inclusion and exclusion criteria, as posted

Inclusion Criteria: * Participants in this study will include typically-developing children between 8-10 years who have lived with a companion dog in the household for at least 6 months. Exclusion Criteria: * known medical diseases or injuries involving the central nervous or endocrine systems, major physical abnormalities, seizures, and significant sensory, cognitive, or motor impairments, current use of psychoactive medications

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