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Trial · Interventional

TerminatedPhase 4Registry data

Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test

NCTNCT03115320 (opens ClinicalTrials.gov in a new tab)Other idR16172MOther id2016-003959-29Other id2016
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Overview

Status
Terminated
Phase
Phase 4
Enrollment
62 participants (actual)
Sponsor
Tampere University Hospital · Other
Design
Randomized · Open label (no masking)
Countries
1 country

Finland

Start
Jan 2017
Primary completion
Nov 2019
Completion
Dec 2019
First posted
14 Apr 2017
Last update posted
22 Aug 2024
Conditions
Infertility

Timeline

1 trial · 1 stopped early

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
2017201820192020
  1. Ph 4

    Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test

    NCT03115320

    Jan 2017 to Dec 2019

    Terminated

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

The primary aim of this study is to find out if ovulation triggered with hCG provides any additional benefit in comparison to spontaneous LH surge measured with the LH surge home test when transferring frozen-thawed embryo in a natural cycle.

Interventions

  • Human chorionic gonadotropinDrug
  • Home ovulation testOther

Arms2

  • Experimental

    Pregnyl (Human chorionic gonadotropin)

    In this group, patients have natural cycle in frozen-thawed embryo transfer and the ovulation is confirmed by administration of hCG (Pregnyl® 5000 IU). The day of transferring embryo is depending on the day of administration of hCG and the age of the embryo. The day zero day is defined by ovulation triggered by hCG.

  • Other

    Home ovulation test

    The patients randomized to the LH surge group perform the ovulation home test daily from the urine. Thus, the ovulation in this group is corfimed by the urine test. The day of transferring embryo is depending on the positive ovulation test and the age of the embryo. The day zero day is defined by positive ovulation test.

Primary outcomes1

Outcomes the sponsor listed as primary.

  1. Live birth rate

    Time frame · At possible delivery (about 40 weeks)

    Registry description

    Live birth rate

Secondary outcomes(1)

  1. Ongoing pregnancy rate

    Time frame · After two weeks

    Registry description

    Ongoing pregnancy rate

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

A trial that is still running, or that stopped early, may post results later.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies0

Studies that cite this trial.

No study cites this trial.

Eligibility

Who could join, as posted.

Sex
Female
Age
from 18 Years up to 42 Years
Healthy volunteers
Not accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * \- Patient with IVF or ICSI cycle and therefore having frozen-thawed embryos * Regular menstruation cycle * Patient's willingness to participate in the study Exclusion Criteria: * \- Irregular menstrual cycle demanding preparing endometrium with hormones for frozen-thawed embryo * No frozen embryos after IVF cycle * Allergy to Pregnyl® or some of its ingredients in the medication or other contraindications due to Pregnyl®

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