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Trial · Interventional

CompletedNot applicableRegistry data

The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

NCTNCT03031405 (opens ClinicalTrials.gov in a new tab)Other idCharite2017-Oxytocin-Study
Open at ClinicalTrials.govAsk about this trial

Overview

Status
Completed
Phase
Not applicable
Enrollment
220 participants (actual)
Sponsor
Charite University, Berlin, Germany · Other
Design
Randomized · Triple masking
Countries
1 country

Germany

Start
15 Jan 2017
Primary completion
30 Jun 2018
Completion
30 Jun 2018
First posted
25 Jan 2017 (estimated)
Last update posted
21 Aug 2018
Conditions
Intrusive Memories

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
201720182019
  1. N/A

    The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

    NCT03031405

    15 Jan 2017 to 30 Jun 2018

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.

Interventions

  • Oxytocin nasal sprayDrug
  • PlacebosDrug

Arms2

  • Experimental

    Oxytocin and trauma film paradigm

  • Placebo comparator

    Placebo and trauma film paradigm

Primary outcomes1

Outcomes the sponsor listed as primary.

  1. Intrusive memories

    Time frame · four consecutive days

    Registry description

    Influence of oxytocin on the development of intrusive memories measured with an intrusion diary

Secondary outcomes(3)

  1. Noradrenergic System (measured with salivary alpha-amylase - u/ml)

    Time frame · Day 1

    Registry description

    Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase

  2. Genetic polymorphism

    Time frame · four consecutive days

    Registry description

    Influence of genetic polymorphism of the oxytocin receptor on intrusive memories measured with an intrusion diary

  3. Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)

    Time frame · Day 1

    Registry description

    Influence of oxytocin on the HPA-axis measured with salivary cortisol

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies1

Studies that cite this trial.

Studies with results

1 study on this page

Indexing hint: Randomized controlled trial · 2022

2 results

Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women.

Schultebraucks et al. 2022Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacologycited by 21

PMID 34887528PMC8938422DOI 10.1038/s41386-021-01247-4PUB-34887528

CC BY2 results
Download PDFSee results (2)

Eligibility

Who could join, as posted.

Sex
Female
Age
from 18 Years up to 44 Years
Healthy volunteers
Accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * healthy female volunteers * German on a native level Exclusion Criteria: * former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) * any physical illnesses * any medication intake (except oral contraceptive) * history of traumatic experience, e.g. history of sexual abuse or rape * pregnancy or lactation period * follicular phase of menstrual cycle for all women not using oral contraceptives

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