Absolute Change From Baseline in Glycosylated Hemoglobin (HbA1c) at Week 24
| Group | Value (percentage of hemoglobin) | Spread |
|---|---|---|
| Placebo | 0.11 | 0.131 |
| Lixisenatide | -0.77 | 0.137 |
Trial · Interventional
CompletedPhase 3Results postedRegistry dataShort name GETGOAL-L-ASIA
Japan, Philippines, South Korea, Taiwan
1 trial · 1 completed · 1 with posted results
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
The purpose of this study is to evaluate the benefits and risks of lixisenatide (AVE0010), in comparison to placebo, as an add-on treatment to basal insulin with or without sulfonylurea, over a period of 24 weeks of treatment. The primary objective is to assess the effects of lixisenatide, when added to basal insulin, on glycemic control in terms of glycosylated hemoglobin (HbA1c) reduction at Week 24. The secondary objectives are to assess the effects of lixisenatide on body weight, 2-hour postprandial plasma glucose (PPG) after standardized meal challenge test, percentage of patients reaching HbA1c less than 7 percent (%), percentage of patients reaching HbA1c less than or equal to 6.5%, fasting plasma glucose (FPG), change in 7-point self-monitored plasma glucose (SMPG) profiles, change in daily basal insulin and total insulin doses; to evaluate safety, tolerability, pharmacokinetics (PK), and anti-lixisenatide antibody development.
Experimental
Lixisenatide
2-step initiation regimen of lixisenatide: 10 microgram (mcg) once daily (QD) for 1 week, followed by 15 mcg QD for 1 week, then 20 mcg QD up to Week 24.
Placebo comparator
Placebo
2-step initiation regimen of volume matching placebo: 10 mcg QD for 1 week, followed by 15 mcg QD for 1 week, then 20 mcg QD up to Week 24.
Outcomes the sponsor listed as primary.
Absolute Change From Baseline in Glycosylated Hemoglobin (HbA1c) at Week 24
Time frame · Baseline, Week 24
Change was calculated by subtracting baseline value from Week 24 value. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to 3 days after the last dose of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Change From Baseline in 2-hour Postprandial Plasma Glucose (PPG) at Week 24
Time frame · Baseline, Week 24
The 2-hour PPG test measured blood glucose 2 hours after eating a standardized meal. Change was calculated by subtracting baseline value from Week 24 value. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to the last dosing day of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Change From Baseline in Body Weight at Week 24
Time frame · Baseline, Week 24
Change was calculated by subtracting baseline value from Week 24 value. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to 3 days after the last dose of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Change From Baseline in Average 7-Point Self Monitored Plasma Glucose (SMPG) Profile at Week 24
Time frame · Baseline, Week 24
Patients recorded a 7-point plasma glucose profile measured before and 2 hours after each meal and at bedtime once in a week and the average value for the 7-time points was calculated. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to the last dosing day of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Change From Baseline in Fasting Plasma Glucose (FPG) at Week 24
Time frame · Baseline, Week 24
Change was calculated by subtracting baseline value from Week 24 value. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to 1 day after the last dose of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Change From Screening in Total Insulin Dose at Week 24
Time frame · Screening, Week 24
Change was calculated by subtracting screening value from Week 24 value. The on-treatment period for this efficacy variable is the time from the first dose of study drug up to the last dosing day of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Percentage of Patients With Glycosylated Hemoglobin (HbA1c) Level Less Than 7% at Week 24
Time frame · Week 24
The on-treatment period for this efficacy variable is the time from the first dose of study drug up to 3 days after the last dose of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Percentage of Patients With Glycosylated Hemoglobin (HbA1c) Level Less Than or Equal to 6.5% at Week 24
Time frame · Week 24
The on-treatment period for this efficacy variable is the time from the first dose of study drug up to 3 days after the last dose of study drug or up to the introduction of rescue therapy, whichever is the earliest. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Percentage of Patients Requiring Rescue Therapy During 24-Week Period
Time frame · Baseline up to Week 24
Routine fasting SMPG and central laboratory FPG (and HbA1c after week 12) values were used to determine the requirement of rescue medication. If fasting SMPG value exceeded the specified limit for 3 consecutive days, the central laboratory FPG (and HbA1c after week 12) were performed. Threshold values - from baseline to Week 8: fasting SMPG/FPG \>270 milligram/deciliter (mg/dL) (15.0 mmol/L), from Week 8 to Week 12: fasting SMPG/FPG \>240 mg/dL (13.3 mmol/L), and from Week 12 to Week 24: fasting SMPG/FPG \>200 mg/dL (11.1 mmol/L) or HbA1c \>8.5%. For a patient to be included in mITT population, both baseline and at least 1 post baseline assessment for at least 1 efficacy variable, were required.
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
| Group | Value (percentage of hemoglobin) | Spread |
|---|---|---|
| Placebo | 0.11 | 0.131 |
| Lixisenatide | -0.77 | 0.137 |
| Group | Value (mmol/L) | Spread |
|---|---|---|
| Placebo | -0.14 | 0.563 |
| Lixisenatide | -7.96 | 0.598 |
| Group | Value (kilogram) | Spread |
|---|---|---|
| Placebo | 0.06 | 0.271 |
| Lixisenatide | -0.38 | 0.284 |
| Group | Value (mmol/L) | Spread |
|---|---|---|
| Placebo | -0.56 | 0.271 |
| Lixisenatide | -1.91 | 0.272 |
| Group | Value (mmol/L) | Spread |
|---|---|---|
| Placebo | 0.25 | 0.302 |
| Lixisenatide | -0.42 | 0.314 |
| Group | Value (units per day) | Spread |
|---|---|---|
| Placebo | -0.11 | 0.442 |
| Lixisenatide | -1.39 | 0.458 |
| Group | Value (percentage of participants) |
|---|---|
| Placebo | 5.2 |
| Lixisenatide | 35.6 |
| Group | Value (percentage of participants) |
|---|---|
| Placebo | 1.3 |
| Lixisenatide | 17.8 |
| Group | Deaths | Serious events | Other events |
|---|---|---|---|
| Placebo2-step initiation regimen up to a maintenance dose of 20 mcg of volume matching placebo. | – | 9 / 157 | 71 / 157 |
| Lixisenatide2-step initiation regimen up to a maintenance dose of 20 mcg of lixisenatide. | – | 10 / 154 | 125 / 154 |
Each cell reads participants affected / participants at risk, as the registry posted them.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies that cite this trial.
3 studies on this page
PubMed tag: none · 2020
Davidson et al. 2020Clinical diabetes and endocrinologycited by 5
PMID 31956422PMC6961286DOI 10.1186/s40842-019-0088-5PUB-31956422
Indexing hint: Randomized controlled trial · 2015
Seino et al. 2015Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismecited by 11
PMID 26039935DOI 10.1055/s-0035-1549875PUB-26039935
Indexing hint: Randomized controlled trial · 2012
Seino et al. 2012Diabetes, obesity & metabolismcited by 222
PMID 22564709PMC3466411DOI 10.1111/j.1463-1326.2012.01618.xPUB-22564709
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